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Crystal structure of a surface mutant of human fetal-specific CYP3A7 bound to dithiothreitol

X-ray diffraction
2.15Å resolution
PDB entry 7mk8 coloured by chain, front view.
PDB entry 7mk8 coloured by chain, side view.
PDB entry 7mk8 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cytochrome P450 3A7
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Multimeric state: homo dimer
Accessible surface area: 39497.57 Å2
Buried surface area: 4923.57 Å2
Dissociation area: 567.1 Å2
Dissociation energy (ΔGdiss): -0.64 kcal/mol
Dissociation entropy (TΔSdiss): 14.2 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-540742

Macromolecules

Cytochrome P450 3A7
Chains: A, B
Length: 519 amino acids
Theoretical weight: 59.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P24462 (Residues: 23-499; Coverage: 95%)
  • Best match: P24462-2 (Residues: 23-535)
Gene name: CYP3A7
Pfam: Cytochrome P450
InterPro:
Cytochrome P450 3A7 in PDB entry 7mk8, assembly 1, front view.
Cytochrome P450 3A7 in PDB entry 7mk8, assembly 1, side view.
Cytochrome P450 3A7 in PDB entry 7mk8, assembly 1, top view.
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