7mxd

Electron Microscopy
3.4Å resolution

Cryo-EM structure of broadly neutralizing V2-apex-targeting antibody J038 in complex with HIV-1 Env

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetradecamer (preferred)
PDBe Complex ID:
PDB-CPX-207914 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (11 distinct):
Envelope glycoprotein gp160 Chains: A, F, G
Molecule details ›
Chains: A, F, G
Length: 478 amino acids
Theoretical weight: 54.23 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: I6NF57 (Residues: 30-505; Coverage: 56%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
3BNC117 antibody heavy chain Chains: C, J, S
Molecule details ›
Chains: C, J, S
Length: 226 amino acids
Theoretical weight: 24.66 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
3BNC117 antibody light chain Chains: D, K, U
J038 antibody heavy chain Chain: X
J038 antibody light chain Chain: Y
Transmembrane protein gp41 Chains: B, H, I

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-24071
Expression system: Homo sapiens