7mxp

Electron Microscopy
4.46Å resolution

Cryo-EM structure of NTD-directed neutralizing antibody LP5 Fab in complex with SARS-CoV-2 S2P spike

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
PDBe Complex ID:
PDB-CPX-225362 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (6 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1288 amino acids
Theoretical weight: 142.46 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1208; Coverage: 95%)
Gene names: 2, S
Sequence domains:
LP5 Fab Heavy Chain Chains: G, H, I
Molecule details ›
Chains: G, H, I
Length: 119 amino acids
Theoretical weight: 13.26 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
LP5 Fab Light Chain Chains: J, K, L
Molecule details ›
Chains: J, K, L
Length: 107 amino acids
Theoretical weight: 11.45 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, FUC
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.46Å
Relevant EMDB volumes: EMD-24075
Expression system: Homo sapiens