› 7n27

X-ray diffraction
1.85Å resolution

Crystal Structure of chromodomain of CDYL in complex with inhibitor UNC6261

Released:
DOI: 10.2210/pdb7n27/pdb
PDB entry 7n27 coloured by chain, front view.
PDB entry 7n27 coloured by chain, side view.
PDB entry 7n27 coloured by chain, top view.
Source organisms:
Entry authors: Beldar S, Dong A, Loppnau P, Min J, Arrowsmith CH, Edwards AM, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-168513 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Isoform 2 of Chromodomain Y-like protein Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 57 amino acids
Theoretical weight: 7.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
inhibitor UNC6261 Chains: G, H, I, J, K, L
Molecule details ›
Chains: G, H, I, J, K, L
Length: 6 amino acids
Theoretical weight: 920 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand NA 2 x NA
Ligand UNX 2 x UNX
1 modified residue:
Ligand PF5 6 x PF5

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P212121
Unit cell:
a: 62.971Å b: 76.386Å c: 80.628Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.225 0.262
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

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