› 7n4v

Electron Microscopy
3.58Å resolution

Structure of cholesterol-bound human NPC1L1

Released:
DOI: 10.2210/pdb7n4v/pdb
PDB entry 7n4v coloured by chain, front view.
PDB entry 7n4v coloured by chain, side view.
PDB entry 7n4v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption.
Long T, Liu Y, Qin Y, DeBose-Boyd RA, Li X
OpenAccess logo Sci Adv 7 (2021)
PMID: 34407950
Related structures: EMD-24179

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193739 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
NPC1-like intracellular cholesterol transporter 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 1332 amino acids
Theoretical weight: 145.9 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UHC9 (Residues: 1-1359; Coverage: 98%)
  • Best match: Q9UHC9-2 (Residues: 1-1332)
Gene name: NPC1L1
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Ligand NAG 12 x NAG
3 bound ligands:
Ligand NAG 8 x NAG
Ligand CLR 6 x CLR
Ligand POV 2 x POV
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.58Å
Relevant EMDB volumes: EMD-24179
Expression system: Homo sapiens

Quick links

Citations

5 review citations

Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics.
Duan et al. (2022)
4 more

1 mention without citation

Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption.
Long et al. (2021)