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Structure of cholesterol-bound human NPC1L1

Electron Microscopy
3.58Å resolution
PDB entry 7n4v coloured by chain, front view.
PDB entry 7n4v coloured by chain, side view.
PDB entry 7n4v coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: NPC1-like intracellular cholesterol transporter 1
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Multimeric state: homo dimer
Accessible surface area: 80006.6 Å2
Buried surface area: 9826.46 Å2
Dissociation area: 838.13 Å2
Dissociation energy (ΔGdiss): 0.06 kcal/mol
Dissociation entropy (TΔSdiss): 16.33 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-193739

Macromolecules

NPC1-like intracellular cholesterol transporter 1
Chains: A, B
Length: 1332 amino acids
Theoretical weight: 145.9 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UHC9 (Residues: 1-1359; Coverage: 98%)
  • Best match: Q9UHC9-2 (Residues: 1-1332)
Gene name: NPC1L1
Pfam:
InterPro:
NPC1-like intracellular cholesterol transporter 1 in PDB entry 7n4v, assembly 1, front view.
NPC1-like intracellular cholesterol transporter 1 in PDB entry 7n4v, assembly 1, side view.
NPC1-like intracellular cholesterol transporter 1 in PDB entry 7n4v, assembly 1, top view.
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