› 7n4y

Electron Microscopy
2.61Å resolution

The structure of bovine thyroglobulin with iodinated tyrosines

Released:
DOI: 10.2210/pdb7n4y/pdb
PDB entry 7n4y coloured by chain, front view.
PDB entry 7n4y coloured by chain, side view.
PDB entry 7n4y coloured by chain, top view.
Source organism: Bos indicus x Bos taurus
Primary publication:
The structure of natively iodinated bovine thyroglobulin.
Kim K, Kopylov M, Bobe D, Kelley K, Eng ET, Arvan P, Clarke OB
OpenAccess logo Acta Crystallogr D Struct Biol 77 1451-1459 (2021)
PMID: 34726172
Related structures: EMD-24181

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-105228 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
Thyroglobulin Chains: A, B
Molecule details ›
Chains: A, B
Length: 2751 amino acids
Theoretical weight: 303.09 KDa
Source organism: Bos indicus x Bos taurus
UniProt:
  • Canonical: A0A4W2CHS8 (Residues: 20-2770; Coverage: 100%)
Gene name: TG
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
1 bound ligand:
Ligand NAG 10 x NAG
1 modified residue:
Ligand TYI 2 x TYI

Experiments and Validation Details

Entry percentile scores
Resolution: 2.61Å
Relevant EMDB volumes: EMD-24181

Quick links

Citations

2 review citations

A glance at post-translational modifications of human thyroglobulin: potential impact on function and pathogenesis.
Tosatto et al. (2022)
1 more

1 mention without citation

The structure of natively iodinated bovine thyroglobulin.
Kim et al. (2021)