7n5h

Electron Microscopy
3.24Å resolution

Cryo-EM structure of broadly neutralizing antibody 2-36 in complex with prefusion SARS-CoV-2 spike glycoprotein

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
PDBe Complex ID:
PDB-CPX-225363 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1288 amino acids
Theoretical weight: 142.4 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1208; Coverage: 95%)
Gene names: 2, S
Sequence domains:
2-36 Fab heavy chain Chains: E, H, J
Molecule details ›
Chains: E, H, J
Length: 128 amino acids
Theoretical weight: 14.15 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
2-36 Fab light chain Chains: F, K, L
Molecule details ›
Chains: F, K, L
Length: 108 amino acids
Theoretical weight: 11.63 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.24Å
Relevant EMDB volumes: EMD-24190
Expression system: Homo sapiens