› 7n75

Electron Microscopy
2.9Å resolution

Cryo-EM structure of ATP13A2 D458N/D962N mutant in the E1-apo state, Conformation 1

Released:
DOI: 10.2210/pdb7n75/pdb
PDB entry 7n75 coloured by chain, front view.
PDB entry 7n75 coloured by chain, side view.
PDB entry 7n75 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of polyamine transport by human ATP13A2 (PARK9).
Sim SI, von Bülow S, Hummer G, Park E
Mol Cell 81 4635-4649.e8 (2021)
PMID: 34715013
Related structures: EMD-24220

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192494 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polyamine-transporting ATPase 13A2 Chain: A
Molecule details ›
Chain: A
Length: 1175 amino acids
Theoretical weight: 128.44 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NQ11 (Residues: 1-1180; Coverage: 100%)
  • Best match: Q9NQ11-3 (Residues: 1-1175)
Gene names: ATP13A2, PARK9
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-24220
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

P-type ATPases: Many more enigmas left to solve.
Palmgren M. (2023)
1 more

2 mentions without citation

Structural basis of polyamine transport by human ATP13A2 (PARK9).
Sim et al. (2021)
1 more