› 7n98

Electron Microscopy
3.5Å resolution

Cryo-EM structure of MFSD2A

Released:
DOI: 10.2210/pdb7n98/pdb
PDB entry 7n98 coloured by chain, front view.
PDB entry 7n98 coloured by chain, side view.
PDB entry 7n98 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure and mechanism of blood-brain-barrier lipid transporter MFSD2A.
Wood CAP, Zhang J, Aydin D, Xu Y, Andreone BJ, Langen UH, Dror RO, Gu C, Feng L
Nature 596 444-448 (2021)
PMID: 34349262
Related structures: EMD-24252

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190075 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium-dependent lysophosphatidylcholine symporter 1 Chain: A
Molecule details ›
Chain: A
Length: 534 amino acids
Theoretical weight: 59.04 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9DA75 (Residues: 1-534; Coverage: 100%)
Gene names: Mfsd2, Mfsd2a, Nls1
Sequence domains: MFS/sugar transport protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-24252
Expression system: Homo sapiens

Quick links

Citations

8 review citations

The Neurovasculome: Key Roles in Brain Health and Cognitive Impairment: A Scientific Statement From the American Heart Association/American Stroke Association.
Iadecola et al. (2023)
7 more

5 mentions without citation

Structure and mechanism of blood-brain-barrier lipid transporter MFSD2A.
Wood et al. (2021)
4 more