› 7n9c

Electron Microscopy
3.71Å resolution

Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting novel and conserved epitopes-CovS with NB95

Released:
DOI: 10.2210/pdb7n9c/pdb
PDB entry 7n9c coloured by chain, front view.
PDB entry 7n9c coloured by chain, side view.
PDB entry 7n9c coloured by chain, top view.
Source organisms:
Primary publication:
Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes
Sun D, Sang Z, Kim YJ, Xiang Y, Cohen T, Belford AK, Huet A, Conway JF, Sun J, Taylor DJ, Schneidman-Duhovny D, Zhang C, Huang W, Shi Y
Nat Commun 12 4676- (2021)
Related structures: EMD-24256

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210254 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1380 amino acids
Theoretical weight: 152.31 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1208; Coverage: 95%)
Gene names: 2, S
Sequence domains:
Nanobody NB95 Chains: D, E
Molecule details ›
Chains: D, E
Length: 155 amino acids
Theoretical weight: 17.15 KDa
Source organism: Lama glama
Expression system: Escherichia coli BL21(DE3)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.71Å
Relevant EMDB volumes: EMD-24256
Expression systems:
  • Homo sapiens
  • Escherichia coli BL21(DE3)

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