› 7n9f

Electron Microscopy
37Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 448-mer (preferred)
PDBe Complex ID:
PDB-CPX-147150 (preferred)
Entry contents:
21 distinct polypeptide molecules
Macromolecules (21 distinct):
Nucleoporin NUP170 Chains: 0, Y
Molecule details ›
Chains: 0, Y
Length: 1502 amino acids
Theoretical weight: 169.65 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: P38181 (Residues: 1-1502; Coverage: 100%)
Gene names: NLE3, NUP170, YBL0725, YBL079W
Sequence domains:
Nucleoporin NUP157 Chains: 1, Z
Molecule details ›
Chains: 1, Z
Length: 1391 amino acids
Theoretical weight: 156.83 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: P40064 (Residues: 1-1391; Coverage: 100%)
Gene names: NUP157, YER105C
Sequence domains:
orphans bound to Nup192 NTD Chains: 5, 6
Molecule details ›
Chains: 5, 6
Length: 36 amino acids
Theoretical weight: 3.08 KDa
Source organism: Saccharomyces cerevisiae
Nucleoporin NSP1 Chains: A, D, G, J, y, z
Molecule details ›
Chains: A, D, G, J, y, z
Length: 823 amino acids
Theoretical weight: 86.61 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: P14907 (Residues: 1-823; Coverage: 100%)
Gene names: J1207, NSP1, YJL041W
Sequence domains: Nsp1-like C-terminal region
Nucleoporin NUP57 Chains: B, E, H, K
Molecule details ›
Chains: B, E, H, K
Length: 541 amino acids
Theoretical weight: 57.55 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: P48837 (Residues: 1-541; Coverage: 100%)
Gene names: G6320, NUP57, YGR119C
Sequence domains:
Nucleoporin NUP49/NSP49 Chains: C, F, I, L
Molecule details ›
Chains: C, F, I, L
Length: 472 amino acids
Theoretical weight: 49.17 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q02199 (Residues: 1-472; Coverage: 100%)
Gene names: G1648, NSP49, NUP49, YGL172W
Sequence domains: Nucleoporin FG repeat region
Nucleoporin NUP192 Chains: M, O
Molecule details ›
Chains: M, O
Length: 1683 amino acids
Theoretical weight: 191.72 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: P47054 (Residues: 1-1683; Coverage: 100%)
Gene names: J1216, NUP192, YJL039C
Sequence domains: Nuclear pore complex scaffold, nucleoporins 186/192/205
Nucleoporin NUP188 Chains: N, P
Molecule details ›
Chains: N, P
Length: 1655 amino acids
Theoretical weight: 188.75 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: P52593 (Residues: 1-1655; Coverage: 100%)
Gene names: NUP188, YML103C
Sequence domains:
Nucleoporin NIC96 Chains: Q, R, S, T
Molecule details ›
Chains: Q, R, S, T
Length: 839 amino acids
Theoretical weight: 96.29 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: P34077 (Residues: 1-839; Coverage: 100%)
Gene names: NIC96, YFR002W
Sequence domains: Nup93/Nic96
Nucleoporin NUP53 Chains: U, W
Molecule details ›
Chains: U, W
Length: 475 amino acids
Theoretical weight: 52.69 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q03790 (Residues: 1-475; Coverage: 100%)
Gene names: NUP53, YM8520.02, YMR153W
Sequence domains: Nup53/35/40-type RNA recognition motif
Nucleoporin ASM4 Chains: V, X
Molecule details ›
Chains: V, X
Length: 528 amino acids
Theoretical weight: 58.85 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q05166 (Residues: 1-528; Coverage: 100%)
Gene names: ASM4, D2420, NUP59, YDL088C
Sequence domains: Nup53/35/40-type RNA recognition motif
Nucleoporin NUP82 Chains: u, v
Molecule details ›
Chains: u, v
Length: 713 amino acids
Theoretical weight: 82.17 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: P40368 (Residues: 1-713; Coverage: 100%)
Gene names: HRB187, J1135, NUP82, YJL061W
Nucleoporin NUP159 Chains: w, x
Molecule details ›
Chains: w, x
Length: 1460 amino acids
Theoretical weight: 159.07 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: P40477 (Residues: 1-1460; Coverage: 100%)
Gene names: NUP158, NUP159, RAT7, YIL115C
Sequence domains: Nucleoporin or Nuclear pore complex subunit NUP214=Nup159
Nucleoporin NUP120 Chains: a, h
Molecule details ›
Chains: a, h
Length: 1037 amino acids
Theoretical weight: 120.56 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: P35729 (Residues: 1-1037; Coverage: 100%)
Gene names: NUP120, RAT2, YKL057C, YKL313, YKL314
Sequence domains: Nucleoporin NUP120, helical domain
Nucleoporin NUP85 Chains: b, i
Molecule details ›
Chains: b, i
Length: 744 amino acids
Theoretical weight: 84.97 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: P46673 (Residues: 1-744; Coverage: 100%)
Gene names: J1624, NUP85, RAT9, YJR042W
Sequence domains: Nup85 Nucleoporin
Nucleoporin NUP145C Chains: c, j
Molecule details ›
Chains: c, j
Length: 712 amino acids
Theoretical weight: 81.16 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: P49687 (Residues: 606-1317; Coverage: 54%)
Gene names: NUP145, RAT10, YGL092W
Sequence domains: Nuclear protein 96
Protein transport protein SEC13 Chains: d, k
Molecule details ›
Chains: d, k
Length: 297 amino acids
Theoretical weight: 33.08 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q04491 (Residues: 1-297; Coverage: 100%)
Gene names: ANU3, L8167.4, SEC13, YLR208W
Sequence domains: WD domain, G-beta repeat
Nucleoporin SEH1 Chains: e, l
Molecule details ›
Chains: e, l
Length: 349 amino acids
Theoretical weight: 39.17 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: P53011 (Residues: 1-349; Coverage: 100%)
Gene names: SEH1, YGL100W
Sequence domains: WD domain, G-beta repeat
Nucleoporin NUP84 Chains: f, m
Molecule details ›
Chains: f, m
Length: 726 amino acids
Theoretical weight: 83.72 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: P52891 (Residues: 1-726; Coverage: 100%)
Gene names: NUP84, YDL116W
Sequence domains: Nuclear pore protein 84 / 107
Nucleoporin NUP133 Chains: g, n
Molecule details ›
Chains: g, n
Length: 1157 amino acids
Theoretical weight: 133.45 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: P36161 (Residues: 1-1157; Coverage: 100%)
Gene names: NUP133, RAT3, YKR082W, YKR402
Sequence domains: Nup133 N terminal like
Dynein light chain 1, cytoplasmic Chains: o, p, q, r, s, t
Molecule details ›
Chains: o, p, q, r, s, t
Length: 92 amino acids
Theoretical weight: 10.46 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q02647 (Residues: 1-92; Coverage: 100%)
Gene names: DYN2, SLC1, YDR424C
Sequence domains: Dynein light chain type 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 37Å
Relevant EMDB volumes: EMD-24258

Quick links

Citations

22 review citations

The Nuclear Pore Complex: Birth, Life, and Death of a Cellular Behemoth.
Dultz et al. (2022)
21 more

4 mentions without citation

Mapping molecular complexes with super-resolution microscopy and single-particle analysis.
Mendes et al. (2022)
3 more