› 7n9o

X-ray diffraction
2Å resolution

Estrogen Receptor Alpha Ligand Binding Domain in Complex with Aliphatic SERD S-C10(15)

Released:
DOI: 10.2210/pdb7n9o/pdb
PDB entry 7n9o coloured by chain, front view.
PDB entry 7n9o coloured by chain, side view.
PDB entry 7n9o coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Diennet M, El Ezzy M, Thiombane K, Cotnoir-White D, Poupart J, Gao Z, Mendoza SR, Marinier A, Gleason J, Mader SC, Fanning SW

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136919 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen receptor Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 249 amino acids
Theoretical weight: 28.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P03372 (Residues: 306-554; Coverage: 42%)
Gene names: ESR, ESR1, NR3A1
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

1 bound ligand:
Ligand 5YR 4 x 5YR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P32
Unit cell:
a: 58.158Å b: 58.158Å c: 274.394Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.184 0.182 0.225
Expression system: Escherichia coli

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