7na7

Electron Microscopy
2.7Å resolution

Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-211371 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Guanine nucleotide-binding protein G(i) subunit alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 354 amino acids
Theoretical weight: 40.43 KDa
Source organism: Homo sapiens
Expression system: Insect expression vector pBlueBacmsGCA1His
UniProt:
  • Canonical: P63096 (Residues: 1-354; Coverage: 100%)
Gene name: GNAI1
Sequence domains: G-protein alpha subunit
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 340 amino acids
Theoretical weight: 37.42 KDa
Source organism: Homo sapiens
Expression system: Insect expression vector pBlueBacmsGCA1His
UniProt:
  • Canonical: P62873 (Residues: 1-340; Coverage: 100%)
Gene name: GNB1
Sequence domains: WD domain, G-beta repeat
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: G
Antibody fragment Chain: N
Growth hormone secretagogue receptor type 1 Chain: R
Ghrelin-27 Chain: L

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.7Å
Relevant EMDB volumes: EMD-24267
Expression systems:
  • Insect expression vector pBlueBacmsGCA1His
  • Not provided