› 7nb6

Electron Microscopy
3.3Å resolution

Structure of the autoinducer-2 exporter TqsA from E. coli

Released:
DOI: 10.2210/pdb7nb6/pdb
PDB entry 7nb6 coloured by chain, front view.
PDB entry 7nb6 coloured by chain, side view.
PDB entry 7nb6 coloured by chain, top view.
Source organism: Escherichia coli K-12
Primary publication:
Cryo-EM structures of pentameric autoinducer-2 exporter from Escherichia coli reveal its transport mechanism.
Khera R, Mehdipour AR, Bolla JR, Kahnt J, Welsch S, Ermler U, Muenke C, Robinson CV, Hummer G, Xie H, Michel H
OpenAccess logo EMBO J e109990 (2022)
PMID: 35698912
Related structures: EMD-12256

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142749 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
AI-2 transport protein TqsA Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 344 amino acids
Theoretical weight: 37.56 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
  • Canonical: P0AFS5 (Residues: 1-344; Coverage: 100%)
Gene names: JW1593, b1601, tqsA, ydgG
Sequence domains: AI-2E family transporter

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-12256
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Mass spectrometry of intact membrane proteins: shifting towards a more native-like context.
Oluwole et al. (2023)
1 more

2 mentions without citation

Modulation of gene expression in contextual fear conditioning in the rat.
Federighi et al. (2013)
1 more