7nd2

Electron Microscopy
4Å resolution

Cryo-EM structure of the human FERRY complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-132060 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Protein phosphatase 1 regulatory subunit 21 Chains: A, B
Molecule details ›
Chains: A, B
Length: 784 amino acids
Theoretical weight: 88.78 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q6ZMI0 (Residues: 1-780; Coverage: 100%)
Gene names: CCDC128, FERRY2, KLRAQ1, PPP1R21
Sequence domains:
Quinone oxidoreductase-like protein 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 356 amino acids
Theoretical weight: 39.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O95825 (Residues: 2-349; Coverage: 100%)
Gene names: 4P11, CRYZL1, FERRY4
Sequence domains: Alcohol dehydrogenase GroES-like domain
Glutamine amidotransferase-like class 1 domain-containing protein 1 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 227 amino acids
Theoretical weight: 24.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8NB37 (Residues: 2-220; Coverage: 100%)
Gene names: FERRY5, GATD1, PDDC1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution:
Relevant EMDB volumes: EMD-12273
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli BL21(DE3)