› 7ne1

X-ray diffraction
3.15Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131961 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Netrin-1 Chain: A
Molecule details ›
Chain: A
Length: 444 amino acids
Theoretical weight: 49.6 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O95631 (Residues: 24-453; Coverage: 74%)
Gene names: NTN1, NTN1L
Sequence domains:
Neogenin Chain: B
Molecule details ›
Chain: B
Length: 354 amino acids
Theoretical weight: 39.27 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q7TQG5 (Residues: 766-1107; Coverage: 24%)
Gene name: Neo1
Sequence domains: Fibronectin type III domain

Ligands and Environments

Carbohydrate polymer : NEW Components: GU4, YYJ
Carbohydrate polymer
3 bound ligands:
Ligand NAG 4 x NAG
Ligand CA 1 x CA
Ligand NO3 3 x NO3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: C2
Unit cell:
a: 150.95Å b: 49.6Å c: 157.25Å
α: 90° β: 99.38° γ: 90°
R-values:
R R work R free
0.214 0.212 0.239
Expression system: Homo sapiens

Quick links

Citations

8 review citations

Unraveling Axon Guidance during Axotomy and Regeneration.
Domínguez-Romero et al. (2021)
7 more

1 mention without citation

Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.
Robinson et al. (2021)