› 7nfa

X-ray diffraction
2.3Å resolution

The structure of the humanised A33 Fab C226S variant, an immunotherapy candidate for colorectal cancer

Released:
DOI: 10.2210/pdb7nfa/pdb
PDB entry 7nfa coloured by chain, front view.
PDB entry 7nfa coloured by chain, side view.
PDB entry 7nfa coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tang J, Zhang C, Dalby P, Kozielski F

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-214411 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
A33 Fab light chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 214 amino acids
Theoretical weight: 23.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli str. K-12 substr. W3110
A33 Fab heavy chain Chains: C, D
Molecule details ›
Chains: C, D
Length: 228 amino acids
Theoretical weight: 23.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli str. K-12 substr. W3110

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P1
Unit cell:
a: 37.669Å b: 69.73Å c: 89.849Å
α: 99.71° β: 101.43° γ: 105.66°
R-values:
R R work R free
0.197 0.193 0.26
Expression system: Escherichia coli str. K-12 substr. W3110

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