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Human mitochondrial Lon protease homolog, D2-state

Source organism: Homo sapiens
Biochemical function: ATP hydrolysis activity
Biological process: protein catabolic process
Cellular component: not assigned

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EC 3.4.21.53: Endopeptidase La

Reaction catalysed:
Hydrolysis of proteins in presence of ATP.
Alternative Name(s):
  • ATP-dependent lon proteinase
  • ATP-dependent protease La
  • ATP-dependent serine proteinase
  • Escherichia coli proteinase La
  • Escherichia coli serine proteinase La
  • Gene lon protease
  • Gene lon proteins
  • Lon proteinase
  • PIM1 protease
  • PIM1 proteinase
  • Protease La
  • Proteinase La
  • Serine protease La

GO terms

Sequence families

Pfam Protein families (Pfam)
PF05362
Domain description: Lon protease (S16) C-terminal proteolytic domain
Occurring in:
  1. Lon protease homolog, mitochondrial
The deposited structure of PDB entry 7ngq contains 6 copies of Pfam domain PF05362 (Lon protease (S16) C-terminal proteolytic domain) in Lon protease homolog, mitochondrial. Showing 1 copy in chain A.

PF22667
Domain description: Lon protease AAA+ ATPase lid domain
Occurring in:
  1. Lon protease homolog, mitochondrial

PF00004
Domain description: ATPase family associated with various cellular activities (AAA)
Occurring in:
  1. Lon protease homolog, mitochondrial
The deposited structure of PDB entry 7ngq contains 6 copies of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in Lon protease homolog, mitochondrial. Showing 1 copy in chain A.

PF02190
Domain description: ATP-dependent protease La (LON) substrate-binding domain
Occurring in:
  1. Lon protease homolog, mitochondrial
The deposited structure of PDB entry 7ngq contains 6 copies of Pfam domain PF02190 (ATP-dependent protease La (LON) substrate-binding domain) in Lon protease homolog, mitochondrial. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR004815
Domain description: Lon protease, bacterial/eukaryotic-type
Occurring in:
  1. Lon protease homolog, mitochondrial
IPR008269
Domain description: Peptidase S16, Lon proteolytic domain
Occurring in:
  1. Lon protease homolog, mitochondrial
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Lon protease homolog, mitochondrial
IPR003111
Domain description: Lon protease, N-terminal domain
Occurring in:
  1. Lon protease homolog, mitochondrial
IPR008268
Domain description: Peptidase S16, active site
Occurring in:
  1. Lon protease homolog, mitochondrial
IPR020568
Domain description: Ribosomal protein uS5 domain 2-type superfamily
Occurring in:
  1. Lon protease homolog, mitochondrial
IPR014721
Domain description: Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
Occurring in:
  1. Lon protease homolog, mitochondrial
IPR003959
Domain description: ATPase, AAA-type, core
Occurring in:
  1. Lon protease homolog, mitochondrial
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. Lon protease homolog, mitochondrial
IPR027065
Domain description: Lon protease
Occurring in:
  1. Lon protease homolog, mitochondrial
IPR015947
Domain description: PUA-like superfamily
Occurring in:
  1. Lon protease homolog, mitochondrial
IPR046336
Domain description: Lon protease, N-terminal domain superfamily
Occurring in:
  1. Lon protease homolog, mitochondrial
IPR027503
Domain description: Lon protease homologue, chloroplastic/mitochondrial
Occurring in:
  1. Lon protease homolog, mitochondrial

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