› 7ngu

X-ray diffraction
1.26Å resolution

Mycobacterium tuberculosis transcriptional regulator EthR with bound inhibitory compound

Released:
DOI: 10.2210/pdb7ngu/pdb
PDB entry 7ngu coloured by chain, front view.
PDB entry 7ngu coloured by chain, side view.
PDB entry 7ngu coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Entry authors: Tomlinson CWE, Tatum NJ, Pohl E

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161781 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH-type transcriptional regulator EthR Chain: A
Molecule details ›
Chain: A
Length: 216 amino acids
Theoretical weight: 23.78 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P9WMC1 (Residues: 1-216; Coverage: 100%)
Gene names: Rv3855, etaR, ethR
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand UAZ 1 x UAZ
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P41212
Unit cell:
a: 121.968Å b: 121.968Å c: 33.728Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.19 0.212
Expression system: Escherichia coli BL21(DE3)

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