Function and Biology Details
Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Influenza RNA-dependent RNA polymerase subunit PB1
- Protein A, Ig-binding domain
- Immunoglobulin/albumin-binding domain superfamily
- PB2, C-terminal
- Influenza RNA-dependent RNA polymerase subunit PB2
- RNA-directed RNA polymerase, negative-strand RNA virus
- Influenza RNA-dependent RNA polymerase subunit PA
- Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain
1 more domain
Structure analysis Details
Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-174538 (preferred)
Entry contents:
3 distinct polypeptide molecules
2 distinct RNA molecules
2 distinct RNA molecules
Macromolecules (5 distinct):
Polymerase acidic protein
Molecule details ›
Chain: A
Length: 716 amino acids
Theoretical weight: 82.71 KDa
Source organism: Influenza A virus (A/Brevig Mission/1/1918(H1N1))
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PA
Length: 716 amino acids
Theoretical weight: 82.71 KDa
Source organism: Influenza A virus (A/Brevig Mission/1/1918(H1N1))
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
Q3HM39 (Residues: 1-716; Coverage: 100%)
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PA
RNA-directed RNA polymerase catalytic subunit
Molecule details ›
Chain: B
Length: 757 amino acids
Theoretical weight: 86.63 KDa
Source organism: Influenza A virus (A/Brevig Mission/1/1918(H1N1))
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PB1
Length: 757 amino acids
Theoretical weight: 86.63 KDa
Source organism: Influenza A virus (A/Brevig Mission/1/1918(H1N1))
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q3HM40 (Residues: 1-757; Coverage: 100%)
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PB1
Polymerase basic protein 2
Molecule details ›
Chain: C
Length: 905 amino acids
Theoretical weight: 102.38 KDa
Source organism: Influenza A virus (A/Brevig Mission/1/1918(H1N1))
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 905 amino acids
Theoretical weight: 102.38 KDa
Source organism: Influenza A virus (A/Brevig Mission/1/1918(H1N1))
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q3HM41 (Residues: 1-759; Coverage: 100%)
Sequence domains:
- Influenza RNA polymerase PB2 N-terminal region
- Influenza RNA polymerase PB2 second domain
- Influenza RNA polymerase PB2 middle domain
- Influenza RNA polymerase PB2 helical domain
- Influenza RNA polymerase PB2 CAP binding domain
- Influenza RNA polymerase PB2 6th domain
- Influenza RNA polymerase PB2 C-terminal domain
