› 7nti

X-ray diffraction
1.98Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128894 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase kinase kinase 7; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 315 amino acids
Theoretical weight: 35.52 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O43318 (Residues: 31-303; Coverage: 45%)
  • Canonical: Q15750 (Residues: 468-504; Coverage: 7%)
Gene names: MAP3K7, MAP3K7IP1, TAB1, TAK1
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

3 bound ligands:
Ligand GOL 5 x GOL
Ligand DMS 2 x DMS
Ligand UWZ 1 x UWZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: I222
Unit cell:
a: 58.165Å b: 134.542Å c: 152.693Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.22 0.249
Expression system: Spodoptera frugiperda

Quick links

Citations

2 mentions without citation

Small-molecule discovery through DNA-encoded libraries.
Peterson et al. (2023)
1 more