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CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC BRANCHED-CHAIN AMINOTRANSFERASE (BCAT1) IN COMPLEX WITH PLP AND SUBSTRATE MIMIC 3-PHENYLPROPIONATE

Source organism: Homo sapiens
Biochemical function: L-isoleucine transaminase activity
Biological process: valine biosynthetic process
Cellular component: cytosol

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EC 2.6.1.42: Branched-chain-amino-acid transaminase

Reaction catalysed:
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate
Systematic name:
Branched-chain-amino-acid:2-oxoglutarate aminotransferase
Alternative Name(s):
  • Branched-chain amino acid aminotransferase
  • Branched-chain amino acid--glutamate transaminase
  • Branched-chain aminotransferase
  • Glutamate--branched-chain amino acid transaminase
  • L-branched chain amino acid aminotransferase
  • Transaminase B

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01063
Domain description: Amino-transferase class IV
Occurring in:
  1. Branched-chain-amino-acid aminotransferase, cytosolic
The deposited structure of PDB entry 7ntr contains 2 copies of Pfam domain PF01063 (Amino-transferase class IV) in Branched-chain-amino-acid aminotransferase, cytosolic. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005786
Domain description: Branched-chain amino acid aminotransferase II
Occurring in:
  1. Branched-chain-amino-acid aminotransferase, cytosolic
IPR018300
Domain description: Aminotransferase, class IV, conserved site
Occurring in:
  1. Branched-chain-amino-acid aminotransferase, cytosolic
IPR043132
Domain description: Branched-chain-amino-acid aminotransferase-like, C-terminal
Occurring in:
  1. Branched-chain-amino-acid aminotransferase, cytosolic
IPR001544
Domain description: Aminotransferase class IV
Occurring in:
  1. Branched-chain-amino-acid aminotransferase, cytosolic
IPR033939
Domain description: Branched-chain aminotransferase
Occurring in:
  1. Branched-chain-amino-acid aminotransferase, cytosolic
IPR036038
Domain description: Aminotransferase-like, PLP-dependent enzymes
Occurring in:
  1. Branched-chain-amino-acid aminotransferase, cytosolic
IPR043131
Domain description: Branched-chain-amino-acid aminotransferase-like, N-terminal
Occurring in:
  1. Branched-chain-amino-acid aminotransferase, cytosolic

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