Function and Biology Details
Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Proliferating cell nuclear antigen, PCNA
- Proliferating cell nuclear antigen, PCNA, conserved site
- DNA clamp superfamily
- Rad18, zinc finger UBZ4-type
- Proliferating cell nuclear antigen, PCNA, C-terminal
- Proliferating cell nuclear antigen, PCNA, N-terminal
- DNA polymerase, Y-family, little finger domain superfamily
- UmuC domain
5 more domains
Structure analysis Details
Assembly composition:
hetero hexamer (preferred)
Assembly name:
PCNA homotrimer and DNA polymerase kappa and DNA (preferred)
PDBe Complex ID:
PDB-CPX-121703 (preferred)
Entry contents:
2 distinct polypeptide molecules
2 distinct DNA molecules
2 distinct DNA molecules
Macromolecules (4 distinct):
Proliferating cell nuclear antigen
Molecule details ›
Chains: B, C, D
Length: 264 amino acids
Theoretical weight: 29.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Length: 264 amino acids
Theoretical weight: 29.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P12004 (Residues: 1-261; Coverage: 100%)
Sequence domains:
DNA polymerase kappa
Molecule details ›
Chain: A
Length: 870 amino acids
Theoretical weight: 98.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Length: 870 amino acids
Theoretical weight: 98.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: Q9UBT6 (Residues: 1-870; Coverage: 100%)
Sequence domains:
