› 7nzy

X-ray diffraction
1.85Å resolution

Crystal structure of human Casein Kinase I delta in complex with CGS-15943

Released:
DOI: 10.2210/pdb7nzy/pdb
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PDB entry 7nzy coloured by chain, front view.
PDB entry 7nzy coloured by chain, side view.
PDB entry 7nzy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Phenotypic Discovery of Triazolo[1,5-c]quinazolines as a First-In-Class Bone Morphogenetic Protein Amplifier Chemotype.
Wesseler F, Lohmann S, Riege D, Halver J, Roth A, Pichlo C, Weber S, Takamiya M, Müller E, Ketzel J, Flegel J, Gihring A, Rastegar S, Bertrand J, Baumann U, Knippschild U, Peifer C, Sievers S, Waldmann H, Schade D
J Med Chem 65 15263-15281 (2022)
PMID: 36346705

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155796 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase I isoform delta Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 314 amino acids
Theoretical weight: 36.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P48730 (Residues: 1-294; Coverage: 71%)
Gene names: CSNK1D, HCKID
Sequence domains: Protein kinase domain

Ligands and Environments

3 bound ligands:
Ligand UX2 4 x UX2
Ligand MLI 4 x MLI
Ligand PO4 4 x PO4
1 modified residue:
Ligand TPO 4 x TPO

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)
Spacegroup: P1
Unit cell:
a: 48.938Å b: 82.081Å c: 89.556Å
α: 87.097° β: 74.264° γ: 86.332°
R-values:
R R work R free
0.205 0.205 0.229
Expression system: Escherichia coli BL21(DE3)

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Citations

2 review citations

Emerging Landscape of Osteogenesis Imperfecta Pathogenesis and Therapeutic Approaches.
Sun et al. (2024)
1 more

1 mention without citation

Mechanism for the activation of the anaplastic lymphoma kinase receptor.
Reshetnyak et al. (2021)

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