› 7o42

Electron Microscopy
4.1Å resolution

TrwK/VirB4unbound trimer of dimers complex (with Hcp1) from the R388 type IV secretion system determined by cryo-EM.

Released:
DOI: 10.2210/pdb7o42/pdb
PDB entry 7o42 coloured by chain, front view.
PDB entry 7o42 coloured by chain, side view.
PDB entry 7o42 coloured by chain, top view.
Source organisms:
Primary publication:
Cryo-EM structure of a type IV secretion system.
Macé K, Vadakkepat AK, Redzej A, Lukoyanova N, Oomen C, Braun N, Ukleja M, Lu F, Costa TRD, Orlova EV, Baker D, Cong Q, Waksman G
OpenAccess logo Nature 607 191-196 (2022)
PMID: 35732732
Related structures: EMD-12716

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108783 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein hcp1; Type IV secretion system protein virB4 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 990 amino acids
Theoretical weight: 111.49 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: A8R751 (Residues: 1-823; Coverage: 100%)
  • Canonical: Q9I747 (Residues: 2-162; Coverage: 99%)
Gene names: PA0085, hcp1, trwK
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.1Å
Relevant EMDB volumes: EMD-12716
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Structural and functional diversity of type IV secretion systems.
Costa et al. (2024)
8 more