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Structure of the alpha subunit of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with oxidized nicotinamide adenine dinucleotide

Source organism: Mycobacterium tuberculosis H37Rv
Biochemical function: NAD+ binding
Biological process: lipid catabolic process
Cellular component: peptidoglycan-based cell wall

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EC 1.1.1.35: 3-hydroxyacyl-CoA dehydrogenase

Reaction catalysed:
(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH
Systematic name:
(S)-3-hydroxyacyl-CoA:NAD(+) oxidoreductase
Alternative Name(s):
  • 1-specific DPN-linked beta-hydroxybutyric dehydrogenase
  • 3-L-hydroxyacyl-CoA dehydrogenase
  • 3-beta-hydroxyacyl coenzyme A dehydrogenase
  • 3-hydroxyacetyl-coenzyme A dehydrogenase
  • 3-hydroxyacyl coenzyme A dehydrogenase
  • 3-hydroxybutyryl-CoA dehydrogenase
  • 3-hydroxyisobutyryl-CoA dehydrogenase
  • 3-keto reductase
  • Beta-hydroxy acid dehydrogenase
  • Beta-hydroxyacyl CoA dehydrogenase
  • Beta-hydroxyacyl dehydrogenase
  • Beta-hydroxyacyl-coenzyme A synthetase
  • Beta-hydroxyacylcoenzyme A dehydrogenase
  • Beta-hydroxybutyrylcoenzyme A dehydrogenase
  • Beta-keto-reductase
  • Beta-ketoacyl-CoA reductase
  • L-3-hydroxyacyl CoA dehydrogenase
  • L-3-hydroxyacyl coenzyme A dehydrogenase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00725
Domain description: 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
Occurring in:
  1. Probable fatty oxidation protein FadB
The deposited structure of PDB entry 7o4u contains 2 copies of Pfam domain PF00725 (3-hydroxyacyl-CoA dehydrogenase, C-terminal domain) in Probable fatty oxidation protein FadB. Showing 1 copy in chain A.

PF02737
Domain description: 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
Occurring in:
  1. Probable fatty oxidation protein FadB
The deposited structure of PDB entry 7o4u contains 2 copies of Pfam domain PF02737 (3-hydroxyacyl-CoA dehydrogenase, NAD binding domain) in Probable fatty oxidation protein FadB. Showing 1 copy in chain A.

PF00378
Domain description: Enoyl-CoA hydratase/isomerase
Occurring in:
  1. Probable fatty oxidation protein FadB
The deposited structure of PDB entry 7o4u contains 2 copies of Pfam domain PF00378 (Enoyl-CoA hydratase/isomerase) in Probable fatty oxidation protein FadB. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR008927
Domain description: 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
Occurring in:
  1. Probable fatty oxidation protein FadB
IPR006108
Domain description: 3-hydroxyacyl-CoA dehydrogenase, C-terminal
Occurring in:
  1. Probable fatty oxidation protein FadB
IPR006176
Domain description: 3-hydroxyacyl-CoA dehydrogenase, NAD binding
Occurring in:
  1. Probable fatty oxidation protein FadB
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. Probable fatty oxidation protein FadB
IPR001753
Domain description: Enoyl-CoA hydratase/isomerase
Occurring in:
  1. Probable fatty oxidation protein FadB
IPR029045
Domain description: ClpP/crotonase-like domain superfamily
Occurring in:
  1. Probable fatty oxidation protein FadB

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