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Crystal Structure of a Class D carbapenemase complexed with Avibactam

Source organism: Klebsiella pneumoniae
Biochemical function: metal ion binding
Biological process: cell wall organization
Cellular component: plasma membrane

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EC 3.5.2.6: Beta-lactamase

Reaction catalysed:
A beta-lactam + H(2)O = a substituted beta-amino acid
Systematic name:
Beta-lactam hydrolase
Alternative Name(s):
  • Ampicillinase
  • Beta-lactamase A, B, C
  • Beta-lactamase AME I
  • Beta-lactamase I-III
  • Cephalosporin-beta-lactamase
  • Cephalosporinase
  • Exopenicillinase
  • Neutrapen
  • Penicillin amido-beta-lactamhydrolase
  • Penicillin beta-lactamase
  • Penicillinase
  • Penicillinase I, II

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00905
Domain description: Penicillin binding protein transpeptidase domain
Occurring in:
  1. Beta-lactamase
The deposited structure of PDB entry 7o5n contains 4 copies of Pfam domain PF00905 (Penicillin binding protein transpeptidase domain) in Beta-lactamase. Showing 1 copy in chain A [auth AAA].

InterPro InterPro annotations
IPR012338
Domain description: Beta-lactamase/transpeptidase-like
Occurring in:
  1. Beta-lactamase
IPR002137
Domain description: Beta-lactamase, class-D active site
Occurring in:
  1. Beta-lactamase
IPR001460
Domain description: Penicillin-binding protein, transpeptidase
Occurring in:
  1. Beta-lactamase

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