› 7o60

Hybrid

Crystal structure of human myelin protein P2 at room temperature from joint X-ray and neutron refinement.

Released:
DOI: 10.2210/pdb7o60/pdb
PDB entry 7o60 coloured by chain, front view.
PDB entry 7o60 coloured by chain, side view.
PDB entry 7o60 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Human myelin protein P2: from crystallography to time-lapse membrane imaging and neuropathy-associated variants.
Uusitalo M, Klenow MB, Laulumaa S, Blakeley MP, Simonsen AC, Ruskamo S, Kursula P
FEBS J 288 6716-6735 (2021)
PMID: 34138518

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136047 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myelin P2 protein Chain: A
Molecule details ›
Chain: A
Length: 133 amino acids
Theoretical weight: 14.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02689 (Residues: 1-132; Coverage: 100%)
Gene name: PMP2
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family

Ligands and Environments

3 bound ligands:
Ligand CIT 1 x CIT
Ligand PLM 1 x PLM
Ligand DOD 105 x DOD
No modified residues

Experiments and Validation Details

Experimental Method: X-ray diffraction, Neutron Diffraction
X-ray source: ILL BEAMLINE LADI III, Xenocs GeniX 3D Cu HF
Spacegroup: P41212
Unit cell:
a: 57.952Å b: 57.952Å c: 100.79Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.16 0.155 0.203
Expression system: Escherichia coli

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Citations

2 review citations

Lipids in Pathophysiology and Development of the Membrane Lipid Therapy: New Bioactive Lipids.
Torres et al. (2021)
1 more

2 mentions without citation

Fatty-Acid-Binding Proteins: From Lipid Transporters to Disease Biomarkers.
Gaffar et al. (2023)
1 more

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