› 7o7b

Solution NMR

Solution NMR Structure of the Neh1 Domain of Human Nuclear factor erythroid 2-related factor 2 (NRF2)

Released:
DOI: 10.2210/pdb7o7b/pdb
PDB entry 7o7b coloured by chain, ensemble of 20 models, front view.
PDB entry 7o7b coloured by chain, ensemble of 20 models, side view.
PDB entry 7o7b coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
A Step toward NRF2-DNA Interaction Inhibitors by Fragment-Based NMR Methods.
Brüschweiler S, Fuchs JE, Bader G, McConnell DB, Konrat R, Mayer M
OpenAccess logo ChemMedChem 16 3576-3587 (2021)
PMID: 34524728

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172457 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear factor erythroid 2-related factor 2 Chain: A
Molecule details ›
Chain: A
Length: 81 amino acids
Theoretical weight: 9.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16236 (Residues: 445-523; Coverage: 13%)
Gene names: NFE2L2, NRF2
Sequence domains: bZIP Maf transcription factor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 56%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

1 mention without citation

A Step toward NRF2-DNA Interaction Inhibitors by Fragment-Based NMR Methods.
Brüschweiler et al. (2021)