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Crystal structure of the human DYRK1A kinase domain bound to abemaciclib

Source organism: Homo sapiens
Biochemical function: ATP binding
Biological process: protein autophosphorylation
Cellular component: not assigned

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EC 2.7.12.1: Dual-specificity kinase

Reaction catalysed:
ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]
Systematic name:
ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating)
Alternative Name(s):
  • ADK1
  • Arabidopsis dual specificity kinase 1
  • CLK1
  • DDYRK2
  • Mps1p

EC 2.7.11.23: [RNA-polymerase]-subunit kinase

Reaction catalysed:
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
Systematic name:
ATP:[DNA-directed RNA polymerase] phosphotransferase
Alternative Name(s):
  • CTD kinase
  • STK9

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00069
Domain description: Protein kinase domain
Occurring in:
  1. Dual specificity tyrosine-phosphorylation-regulated kinase 1A
The deposited structure of PDB entry 7o7k contains 2 copies of Pfam domain PF00069 (Protein kinase domain) in Dual specificity tyrosine-phosphorylation-regulated kinase 1A. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR008271
Domain description: Serine/threonine-protein kinase, active site
Occurring in:
  1. Dual specificity tyrosine-phosphorylation-regulated kinase 1A
IPR017441
Domain description: Protein kinase, ATP binding site
Occurring in:
  1. Dual specificity tyrosine-phosphorylation-regulated kinase 1A
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. Dual specificity tyrosine-phosphorylation-regulated kinase 1A
IPR044131
Domain description: Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain
Occurring in:
  1. Dual specificity tyrosine-phosphorylation-regulated kinase 1A
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Dual specificity tyrosine-phosphorylation-regulated kinase 1A

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