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(h-alpha2M)4 trypsin-activated state

Source organism: Homo sapiens
Biochemical function: endopeptidase inhibitor activity
Biological process: not assigned
Cellular component: extracellular space

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GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF07677
Domain description: A-macroglobulin receptor binding domain
Occurring in:
  1. Alpha-2-macroglobulin
The deposited structure of PDB entry 7o7q contains 4 copies of Pfam domain PF07677 (A-macroglobulin receptor binding domain) in Alpha-2-macroglobulin. Showing 1 copy in chain A (this domain is out of the observed residue ranges!).

PF07678
Domain description: A-macroglobulin TED domain
Occurring in:
  1. Alpha-2-macroglobulin
The deposited structure of PDB entry 7o7q contains 4 copies of Pfam domain PF07678 (A-macroglobulin TED domain) in Alpha-2-macroglobulin. Showing 1 copy in chain A.

PF00207
Domain description: Alpha-2-macroglobulin family
Occurring in:
  1. Alpha-2-macroglobulin
The deposited structure of PDB entry 7o7q contains 4 copies of Pfam domain PF00207 (Alpha-2-macroglobulin family) in Alpha-2-macroglobulin. Showing 1 copy in chain A.

PF07703
Domain description: Alpha-2-macroglobulin bait region domain
Occurring in:
  1. Alpha-2-macroglobulin
The deposited structure of PDB entry 7o7q contains 4 copies of Pfam domain PF07703 (Alpha-2-macroglobulin bait region domain) in Alpha-2-macroglobulin. Showing 1 copy in chain A.

PF17789
Domain description: Macroglobulin domain MG4
Occurring in:
  1. Alpha-2-macroglobulin
The deposited structure of PDB entry 7o7q contains 4 copies of Pfam domain PF17789 (Macroglobulin domain MG4) in Alpha-2-macroglobulin. Showing 1 copy in chain A.

PF17791
Domain description: Macroglobulin domain MG3
Occurring in:
  1. Alpha-2-macroglobulin
The deposited structure of PDB entry 7o7q contains 4 copies of Pfam domain PF17791 (Macroglobulin domain MG3) in Alpha-2-macroglobulin. Showing 1 copy in chain A.

PF01835
Domain description: MG2 domain
Occurring in:
  1. Alpha-2-macroglobulin
The deposited structure of PDB entry 7o7q contains 4 copies of Pfam domain PF01835 (MG2 domain) in Alpha-2-macroglobulin. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR009048
Domain description: Alpha-macroglobulin, receptor-binding
Occurring in:
  1. Alpha-2-macroglobulin
IPR036595
Domain description: Alpha-macroglobulin, receptor-binding domain superfamily
Occurring in:
  1. Alpha-2-macroglobulin
IPR011625
Domain description: Alpha-2-macroglobulin, bait region domain
Occurring in:
  1. Alpha-2-macroglobulin
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Alpha-2-macroglobulin
IPR019742
Domain description: Alpha-2-macroglobulin, conserved site
Occurring in:
  1. Alpha-2-macroglobulin
IPR047565
Domain description: Alpha-macroglobulin-like, thiol-ester bond-forming region
Occurring in:
  1. Alpha-2-macroglobulin
IPR041813
Domain description: Alpha-2-macroglobulin, TED domain
Occurring in:
  1. Alpha-2-macroglobulin
IPR008930
Domain description: Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Occurring in:
  1. Alpha-2-macroglobulin
IPR011626
Domain description: Alpha-macroglobulin-like, TED domain
Occurring in:
  1. Alpha-2-macroglobulin
IPR014756
Domain description: Immunoglobulin E-set
Occurring in:
  1. Alpha-2-macroglobulin
IPR001599
Domain description: Alpha-2-macroglobulin
Occurring in:
  1. Alpha-2-macroglobulin
IPR040839
Domain description: Macroglobulin domain MG4
Occurring in:
  1. Alpha-2-macroglobulin
IPR041555
Domain description: Macroglobulin domain MG3
Occurring in:
  1. Alpha-2-macroglobulin
IPR002890
Domain description: Macroglobulin domain
Occurring in:
  1. Alpha-2-macroglobulin
IPR010916
Domain description: TonB box, conserved site
Occurring in:
  1. Alpha-2-macroglobulin

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