Function and Biology

MAT in complex with SAMH

Source organisms:
Biochemical function: transferase activity
Biological process: S-adenosylmethionine cycle
Cellular component: cytosol

EC 2.5.1.6: Methionine adenosyltransferase

Reaction catalysed:
ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine
Systematic name:
ATP:L-methionine S-adenosyltransferase
Alternative Name(s):
  • ATP-methionine adenosyltransferase
  • Adenosylmethionine synthetase
  • AdoMet synthetase
  • Methionine S-adenosyltransferase
  • Methionine-activating enzyme
  • S-adenosyl-L-methionine synthetase
  • S-adenosylmethionine synthase
  • S-adenosylmethionine synthetase

Sequence families

Pfam Protein families (Pfam)
PF02773
Domain description: S-adenosylmethionine synthetase, C-terminal domain
Occurring in:
  1. S-adenosylmethionine synthase
The deposited structure of PDB entry 7ock contains 8 copies of Pfam domain PF02773 (S-adenosylmethionine synthetase, C-terminal domain) in S-adenosylmethionine synthase. Showing 1 copy in chain A [auth B].

PF02772
Domain description: S-adenosylmethionine synthetase, central domain
Occurring in:
  1. S-adenosylmethionine synthase
The deposited structure of PDB entry 7ock contains 8 copies of Pfam domain PF02772 (S-adenosylmethionine synthetase, central domain) in S-adenosylmethionine synthase. Showing 1 copy in chain A [auth B].

PF00438
Domain description: S-adenosylmethionine synthetase, N-terminal domain
Occurring in:
  1. S-adenosylmethionine synthase
The deposited structure of PDB entry 7ock contains 8 copies of Pfam domain PF00438 (S-adenosylmethionine synthetase, N-terminal domain) in S-adenosylmethionine synthase. Showing 1 copy in chain A [auth B].

InterPro InterPro annotations
IPR002133
Domain description: S-adenosylmethionine synthetase
Occurring in:
  1. S-adenosylmethionine synthase
IPR022631
Domain description: S-adenosylmethionine synthetase, conserved site
Occurring in:
  1. S-adenosylmethionine synthase
IPR022630
Domain description: S-adenosylmethionine synthetase, C-terminal
Occurring in:
  1. S-adenosylmethionine synthase
IPR022629
Domain description: S-adenosylmethionine synthetase, central domain
Occurring in:
  1. S-adenosylmethionine synthase
IPR022628
Domain description: S-adenosylmethionine synthetase, N-terminal
Occurring in:
  1. S-adenosylmethionine synthase