7oh1

Electron Microscopy
8Å resolution

Tetanus neurotoxin LC-HN domain in complex with TT110-Fab1

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of -Gln(76)-|-Phe- bond in synaptobrevin (also known as neuronal vesicle-associated membrane protein, VAMP).
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-209154 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Tetanus toxin heavy chain Chain: A
Molecule details ›
Chain: A
Length: 870 amino acids
Theoretical weight: 99.92 KDa
Source organism: Clostridium tetani
UniProt:
  • Canonical: P04958 (Residues: 1-870; Coverage: 66%)
Gene names: CTC_p60, tetX
Sequence domains:
FAB TT110 Chain: E
Molecule details ›
Chain: E
Length: 228 amino acids
Theoretical weight: 24.3 KDa
Source organism: Homo sapiens
FAB TT110 Chain: D
Molecule details ›
Chain: D
Length: 212 amino acids
Theoretical weight: 23.02 KDa
Source organism: Homo sapiens

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution:
Relevant EMDB volumes: EMD-12891