› 7oly

X-ray diffraction
3.26Å resolution

Structure of activin A in complex with an ActRIIB-Alk4 fusion reveal insight into activin receptor interactions

Released:
DOI: 10.2210/pdb7oly/pdb
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PDB entry 7oly coloured by chain, front view.
PDB entry 7oly coloured by chain, side view.
PDB entry 7oly coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of activin ligand traps using natural sets of type I and type II TGFβ receptors.
Goebel EJ, Kattamuri C, Gipson GR, Krishnan L, Chavez M, Czepnik M, Maguire MC, Grenha R, Håkansson M, Logan DT, Grinberg AV, Sako D, Castonguay R, Kumar R, Thompson TB
OpenAccess logo iScience 25 103590 (2022)
PMID: 35005539

Function and Biology Details

Reaction catalysed: 
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero decamer (preferred)
PDBe Complex ID:
PDB-CPX-209364 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (6 distinct):
Inhibin beta A chain Chain: A
Molecule details ›
Chain: A
Length: 116 amino acids
Theoretical weight: 12.99 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08476 (Residues: 311-426; Coverage: 29%)
Gene name: INHBA
Sequence domains: Transforming growth factor beta like domain
Activin receptor type-2B Chain: C
Molecule details ›
Chain: C
Length: 133 amino acids
Theoretical weight: 14.93 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13705 (Residues: 19-134; Coverage: 24%)
Gene name: ACVR2B
Sequence domains: Activin types I and II receptor domain
Fab heavy chain Chain: H
Activin receptor type-1B Chain: K
Fab light chain Chain: L

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: MAX IV BEAMLINE BioMAX
Spacegroup: P6122
Unit cell:
a: 68.375Å b: 68.375Å c: 975.538Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.236 0.234 0.268
Expression system: Homo sapiens

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Citations

1 review citation

New aspects of TGF-β superfamily signaling in development and disease (2022 FASEB meeting review).
Newfeld et al. (2022)
4 other articles

4 mentions without citation

The orphan ligand, activin C, signals through activin receptor-like kinase 7.
Goebel et al. (2022)
3 more

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