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Structure of human mitochondrial RNase P in complex with mitochondrial pre-tRNA-Tyr

Electron Microscopy
3Å resolution
PDB entry 7onu coloured by chain, front view.
PDB entry 7onu coloured by chain, side view.
PDB entry 7onu coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero heptamer (preferred)
Entry contents: 3 distinct polypeptide molecules
1 distinct RNA molecule

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero heptamer
Accessible surface area: 74246.32 Å2
Buried surface area: 33177.52 Å2
Dissociation area: 4,281.8 Å2
Dissociation energy (ΔGdiss): 48.92 kcal/mol
Dissociation entropy (TΔSdiss): 15.62 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127288

Macromolecules

3-hydroxyacyl-CoA dehydrogenase type-2
Chains: A, B, C, D
Length: 261 amino acids
Theoretical weight: 26.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q99714 (Residues: 1-261; Coverage: 100%)
Gene names: ERAB, HADH2, HSD17B10, MRPP2, SCHAD, SDR5C1, XH98G2
Pfam: short chain dehydrogenase
InterPro:
3-hydroxyacyl-CoA dehydrogenase type-2 in PDB entry 7onu, assembly 1, front view.
3-hydroxyacyl-CoA dehydrogenase type-2 in PDB entry 7onu, assembly 1, side view.
3-hydroxyacyl-CoA dehydrogenase type-2 in PDB entry 7onu, assembly 1, top view.
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Mitochondrial ribonuclease P catalytic subunit
Chain: E
Length: 541 amino acids
Theoretical weight: 62.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O15091 (Residues: 46-583; Coverage: 92%)
Gene names: KIAA0391, MRPP3, PRORP
Pfam: Protein-only RNase P
InterPro:
Mitochondrial ribonuclease P catalytic subunit in PDB entry 7onu, assembly 1, front view.
Mitochondrial ribonuclease P catalytic subunit in PDB entry 7onu, assembly 1, side view.
Mitochondrial ribonuclease P catalytic subunit in PDB entry 7onu, assembly 1, top view.
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tRNA methyltransferase 10 homolog C
Chain: F
Length: 367 amino acids
Theoretical weight: 42.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q7L0Y3 (Residues: 40-403; Coverage: 90%)
Gene names: MRPP1, RG9MTD1, TRMT10C
Pfam: tRNA (Guanine-1)-methyltransferase
InterPro:
tRNA methyltransferase 10 homolog C in PDB entry 7onu, assembly 1, front view.
tRNA methyltransferase 10 homolog C in PDB entry 7onu, assembly 1, side view.
tRNA methyltransferase 10 homolog C in PDB entry 7onu, assembly 1, top view.
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RNA chain T
Name: Mitochondrial Precursor tRNA-Tyr
Representative chains: T
Length: 128 nucleotides
Theoretical weight: 41.49 KDa
Rfam: tRNA
Mitochondrial Precursor tRNA-Tyr in PDB entry 7onu, assembly 1, front view.
Mitochondrial Precursor tRNA-Tyr in PDB entry 7onu, assembly 1, side view.
Mitochondrial Precursor tRNA-Tyr in PDB entry 7onu, assembly 1, top view.
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