Function and Biology Details
Reactions catalysed:
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + NAD(+) = 3-alpha,12-alpha-dihydroxy-7-oxo-5-beta-cholanate + NADH
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methylacetoacetyl-CoA + NADH
Testosterone + NAD(+) = androstenedione + NADH
(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH
Androstan-3-alpha,17-beta-diol + NAD(+) = 17-beta-hydroxyandrostan-3-one + NADH
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H
Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
S-adenosyl-L-methionine + adenine(9) in tRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(9) in tRNA
S-adenosyl-L-methionine + guanine(9) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(9) in tRNA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Short-chain dehydrogenase/reductase SDR
- Short-chain dehydrogenase/reductase, conserved site
- NAD(P)-binding domain superfamily
- tRNA methyltransferase TRMD/TRM10-type domain
- tRNA methyltransferase 10 homolog C, TRM10-type domain
- tRNA methyltransferase TRM10-type domain superfamily
- tRNA methyltransferase TRM10-type domain
- tRNA (guanine-N1-)-methyltransferase, eukaryotic
4 more domains
Structure analysis Details
Assembly composition:
hetero heptamer (preferred)
PDBe Complex ID:
PDB-CPX-127288 (preferred)
Entry contents:
3 distinct polypeptide molecules
1 distinct RNA molecule
1 distinct RNA molecule
Macromolecules (4 distinct):