› 7opg

X-ray diffraction
1.93Å resolution

Crystal structure of CLK1 in complex with compound 2 (CC513)

Released:
DOI: 10.2210/pdb7opg/pdb
PDB entry 7opg coloured by chain, front view.
PDB entry 7opg coloured by chain, side view.
PDB entry 7opg coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Chaikuad A, Routier S, Bonnet P, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156010 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dual specificity protein kinase CLK1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 339 amino acids
Theoretical weight: 39.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P49759 (Residues: 148-484; Coverage: 70%)
Gene names: CLK, CLK1
Sequence domains: Protein kinase domain

Ligands and Environments

4 bound ligands:
Ligand 06N 3 x 06N
Ligand GOL 10 x GOL
Ligand PO4 2 x PO4
Ligand EPE 1 x EPE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P21
Unit cell:
a: 56.39Å b: 116.93Å c: 91.8Å
α: 90° β: 99.04° γ: 90°
R-values:
R R work R free
0.176 0.175 0.208
Expression system: Escherichia coli BL21(DE3)

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