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HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND INHIBITOR RMC-233

X-ray diffraction
2.95Å resolution
PDB entry 7otk coloured by chain, front view.
PDB entry 7otk coloured by chain, side view.
PDB entry 7otk coloured by chain, top view.
Source organism: Human immunodeficiency virus type 1 BH10
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules
2 distinct DNA molecules

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Assemblies

Assembly 1
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Assembly Name: Protease and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 48788.59 Å2
Buried surface area: 12858.69 Å2
Dissociation area: 2,960.84 Å2
Dissociation energy (ΔGdiss): 25.57 kcal/mol
Dissociation entropy (TΔSdiss): 15.2 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-121746
Assembly 2 (preferred)
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Assembly Name: Protease and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 49346.79 Å2
Buried surface area: 13504.41 Å2
Dissociation area: 2,967.12 Å2
Dissociation energy (ΔGdiss): 26.61 kcal/mol
Dissociation entropy (TΔSdiss): 15.2 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-121746

Macromolecules

Reverse transcriptase/ribonuclease H
Chains: A, C
Length: 556 amino acids
Theoretical weight: 64.02 KDa
Source organism: Human immunodeficiency virus type 1 BH10
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03366 (Residues: 600-1153; Coverage: 38%)
Gene name: gag-pol
Pfam:
InterPro:
Reverse transcriptase/ribonuclease H in PDB entry 7otk, assembly 2, front view.
Reverse transcriptase/ribonuclease H in PDB entry 7otk, assembly 2, side view.
Reverse transcriptase/ribonuclease H in PDB entry 7otk, assembly 2, top view.
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p51 RT
Chains: B, D
Length: 428 amino acids
Theoretical weight: 50.04 KDa
Source organism: Human immunodeficiency virus type 1 BH10
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03366 (Residues: 600-1027; Coverage: 30%)
Gene name: gag-pol
Pfam:
InterPro:
p51 RT in PDB entry 7otk, assembly 2, front view.
p51 RT in PDB entry 7otk, assembly 2, side view.
p51 RT in PDB entry 7otk, assembly 2, top view.
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DNA chains E, T
Name: DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3')
Representative chains: E, T
Length: 27 nucleotides
Theoretical weight: 8.38 KDa
DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3') in PDB entry 7otk, assembly 2, front view.
DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3') in PDB entry 7otk, assembly 2, side view.
DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3') in PDB entry 7otk, assembly 2, top view.
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DNA chains F, P
Name: DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)*CP*GP*CP*CP*(DDG))-3')
Representative chains: F, P
Length: 21 nucleotides
Theoretical weight: 6.47 KDa
DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)*CP*GP*CP*CP*(DDG))-3') in PDB entry 7otk, assembly 2, front view.
DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)*CP*GP*CP*CP*(DDG))-3') in PDB entry 7otk, assembly 2, side view.
DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)*CP*GP*CP*CP*(DDG))-3') in PDB entry 7otk, assembly 2, top view.
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