Structure analysis

EIF6-bound large subunit of the human ribosome

Electron Microscopy
2.4Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero 43-mer (preferred)
Entry contents: 40 distinct polypeptide molecules
3 distinct RNA molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero 43-mer
Accessible surface area: 594727.05 Å2
Buried surface area: 485744.68 Å2
Dissociation area: 934.23 Å2
Dissociation energy (ΔGdiss): 1.96 kcal/mol
Dissociation entropy (TΔSdiss): 2.04 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-250225

Macromolecules

Chain: D
Length: 257 amino acids
Theoretical weight: 28.09 KDa
Source organism: Homo sapiens
125720406080100120140160180200220240
 
100200
UniProt
P62917
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Chain: E
Length: 430 amino acids
Theoretical weight: 48.92 KDa
Source organism: Homo sapiens
143050100150200250300350400
 
200400
Chains
Chain E (auth E)
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Chain: F
Length: 427 amino acids
Theoretical weight: 47.8 KDa
Source organism: Homo sapiens
142750100150200250300350400
 
200400
UniProt
P36578
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Chain: G
Length: 297 amino acids
Theoretical weight: 34.43 KDa
Source organism: Homo sapiens
129720406080100120140160180200220240260280
 
100200
UniProt
P46777
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Chain: H
Length: 288 amino acids
Theoretical weight: 32.9 KDa
Source organism: Homo sapiens
128820406080100120140160180200220240260280
 
100200
UniProt
Q02878
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Chain: m
Length: 248 amino acids
Theoretical weight: 29.29 KDa
Source organism: Homo sapiens
124820406080100120140160180200220240
 
100200
UniProt
P18124
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Chain: n
Length: 266 amino acids
Theoretical weight: 30.06 KDa
Source organism: Homo sapiens
126620406080100120140160180200220240260
 
100200
UniProt
P62424
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Chain: o
Length: 190 amino acids
Theoretical weight: 21.66 KDa
Source organism: Homo sapiens
119020406080100120140160180
 
50100150
UniProt
P32969
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Chain: p
Length: 214 amino acids
Theoretical weight: 24.62 KDa
Source organism: Homo sapiens
121420406080100120140160180200
 
100200
UniProt
Q96L21
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Chain: q
Length: 178 amino acids
Theoretical weight: 20.29 KDa
Source organism: Homo sapiens
117820406080100120140160
 
50100150
UniProt
P62913
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Variants

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Chain: r
Length: 211 amino acids
Theoretical weight: 24.32 KDa
Source organism: Homo sapiens
121120406080100120140160180200
 
50100150200
UniProt
P26373
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Chain: s
Length: 220 amino acids
Theoretical weight: 23.84 KDa
Source organism: Homo sapiens
122020406080100120140160180200220
 
100200
UniProt
Q6IPH7
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Chain: t
Length: 204 amino acids
Theoretical weight: 24.21 KDa
Source organism: Homo sapiens
120420406080100120140160180200
 
50100150200
UniProt
P61313
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Chain: I
Length: 203 amino acids
Theoretical weight: 23.63 KDa
Source organism: Homo sapiens
120320406080100120140160180200
 
50100150200
UniProt
P40429
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Chain: J
Length: 184 amino acids
Theoretical weight: 21.44 KDa
Source organism: Homo sapiens
118420406080100120140160180
 
50100150
UniProt
P18621
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Chain: K
Length: 188 amino acids
Theoretical weight: 21.69 KDa
Source organism: Homo sapiens
118820406080100120140160180
 
50100150
UniProt
Q07020
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Chain: L
Length: 196 amino acids
Theoretical weight: 23.54 KDa
Source organism: Homo sapiens
119620406080100120140160180
 
50100150
UniProt
P84098
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Chain: M
Length: 176 amino acids
Theoretical weight: 20.81 KDa
Source organism: Homo sapiens
117620406080100120140160
 
50100150
UniProt
Q02543
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Chain: N
Length: 160 amino acids
Theoretical weight: 18.61 KDa
Source organism: Homo sapiens
116020406080100120140160
 
50100150
UniProt
P46778
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Chain: R
Length: 156 amino acids
Theoretical weight: 17.74 KDa
Source organism: Homo sapiens
115620406080100120140
 
50100150
UniProt
P62750
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Chain: S
Length: 145 amino acids
Theoretical weight: 17.3 KDa
Source organism: Homo sapiens
114520406080100120140
 
50100
UniProt
P61254
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Chain: T
Length: 136 amino acids
Theoretical weight: 15.84 KDa
Source organism: Homo sapiens
1136102030405060708090100110120130
 
50100
UniProt
P61353
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Chain: U
Length: 148 amino acids
Theoretical weight: 16.6 KDa
Source organism: Homo sapiens
114820406080100120140
 
50100
UniProt
P46776
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Chain: V
Length: 159 amino acids
Theoretical weight: 17.8 KDa
Source organism: Homo sapiens
115920406080100120140
 
50100150
UniProt
P47914
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Chain: W
Length: 115 amino acids
Theoretical weight: 12.81 KDa
Source organism: Homo sapiens
1115102030405060708090100110
 
50100
UniProt
P62888
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Chain: X
Length: 125 amino acids
Theoretical weight: 14.49 KDa
Source organism: Homo sapiens
1125102030405060708090100110120
 
50100
UniProt
P62899
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Chain: Y
Length: 135 amino acids
Theoretical weight: 15.9 KDa
Source organism: Homo sapiens
1135102030405060708090100110120130
 
50100
UniProt
P62910
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Chain: Z
Length: 110 amino acids
Theoretical weight: 12.56 KDa
Source organism: Homo sapiens
1110102030405060708090100110
 
50100
UniProt
P18077
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Chain: a
Length: 117 amino acids
Theoretical weight: 13.33 KDa
Source organism: Homo sapiens
1117102030405060708090100110
 
50100
UniProt
P49207
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Chain: b
Length: 123 amino acids
Theoretical weight: 14.59 KDa
Source organism: Homo sapiens
1123102030405060708090100110120
 
50100
UniProt
P42766
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Chain: c
Length: 105 amino acids
Theoretical weight: 12.29 KDa
Source organism: Homo sapiens
1105102030405060708090100
 
50100
UniProt
Q9Y3U8
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Chain: d
Length: 97 amino acids
Theoretical weight: 11.11 KDa
Source organism: Homo sapiens
197102030405060708090
 
50
UniProt
P61927
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Chain: e
Length: 70 amino acids
Theoretical weight: 8.19 KDa
Source organism: Homo sapiens
170510152025303540455055606570
 
204060MPRKIEEIKDFLLTAPRKDAKSIKIKKNKDNVKFKVRCSRYLYTLVITDKEKAEKLKQSLPPGLAVKELK
UniProt
P63173
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Chain: f
Length: 157 amino acids
Theoretical weight: 18.02 KDa
Source organism: Homo sapiens
115720406080100120140
 
50100150
Chains
Chain KA (auth f)
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Chain: i
Length: 106 amino acids
Theoretical weight: 12.48 KDa
Source organism: Homo sapiens
1106102030405060708090100
 
50100
UniProt
P83881
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Chain: j
Length: 92 amino acids
Theoretical weight: 10.3 KDa
Source organism: Homo sapiens
192102030405060708090
 
20406080
UniProt
P61513
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Chain: k
Length: 137 amino acids
Theoretical weight: 15.78 KDa
Source organism: Homo sapiens
1137102030405060708090100110120130
 
50100
UniProt
P46779
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Chain: P
Length: 245 amino acids
Theoretical weight: 26.62 KDa
Source organism: Homo sapiens
124520406080100120140160180200220240
 
100200
UniProt
P56537
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Chain: Q
Length: 140 amino acids
Theoretical weight: 14.89 KDa
Source organism: Homo sapiens
1140102030405060708090100110120130140
 
50100
UniProt
P62829
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Chain: u
Length: 157 amino acids
Theoretical weight: 17.83 KDa
Source organism: Homo sapiens
115720406080100120140
 
50100150
UniProt
P83731
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Name: 28S ribosomal RNA
Representative chains: A
Source organism: Homo sapiens [9606]
Length: 5070 nucleotides
Theoretical weight: 1641.13 KDa
Rfam: Eukaryotic large subunit ribosomal RNA
150705001,0001,5002,0002,5003,0003,5004,0004,5005,000
 
20004000
Chains
Chain A (auth A)
Rfam
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Name: 5S ribosomal RNA
Representative chains: B
Source organism: Homo sapiens [9606]
Length: 121 nucleotides
Theoretical weight: 39 KDa
Rfam: 5S ribosomal RNA
1121102030405060708090100110120
 
50100
Chains
Chain B (auth B)
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Name: 5.8S ribosomal RNA
Representative chains: C
Source organism: Homo sapiens [9606]
Length: 157 nucleotides
Theoretical weight: 50.46 KDa
Rfam: 5.8S ribosomal RNA
115720406080100120140
 
50100150
Chains
Chain C (auth C)
Rfam
Ligand binding sites
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