7p02

Electron Microscopy
2.87Å resolution

Human Neurokinin 1 receptor (NK1R) substance P Gs complex

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-210787 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Antibody fragment scFv16 Chain: H
Molecule details ›
Chain: H
Length: 298 amino acids
Theoretical weight: 32.41 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 354 amino acids
Theoretical weight: 39.09 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: G
Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Chain: A
Substance-P receptor Chain: R
Substance P Chain: P

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.87Å
Relevant EMDB volumes: EMD-13141
Expression system: Spodoptera frugiperda