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Cryo-EM structure of Pdr5 from Saccharomyces cerevisiae in outward-facing conformation with ADP-orthovanadate/ATP

Source organism: Saccharomyces cerevisiae S288C
Biochemical function: ABC-type transporter activity
Biological process: xenobiotic detoxification by transmembrane export across the plasma membrane
Cellular component: cell periphery

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF01061
Domain description: ABC-2 type transporter
Occurring in:
  1. Pleiotropic ABC efflux transporter of multiple drugs
The deposited structure of PDB entry 7p06 contains 2 copies of Pfam domain PF01061 (ABC-2 type transporter) in Pleiotropic ABC efflux transporter of multiple drugs. Showing 2 copies in chain A.

PF00005
Domain description: ABC transporter
Occurring in:
  1. Pleiotropic ABC efflux transporter of multiple drugs
The deposited structure of PDB entry 7p06 contains 2 copies of Pfam domain PF00005 (ABC transporter) in Pleiotropic ABC efflux transporter of multiple drugs. Showing 2 copies in chain A.

PF06422
Domain description: CDR ABC transporter
Occurring in:
  1. Pleiotropic ABC efflux transporter of multiple drugs
The deposited structure of PDB entry 7p06 contains 1 copy of Pfam domain PF06422 (CDR ABC transporter) in Pleiotropic ABC efflux transporter of multiple drugs. Showing 1 copy in chain A.

PF14510
Domain description: ABC-transporter N-terminal
Occurring in:
  1. Pleiotropic ABC efflux transporter of multiple drugs
The deposited structure of PDB entry 7p06 contains 1 copy of Pfam domain PF14510 (ABC-transporter N-terminal) in Pleiotropic ABC efflux transporter of multiple drugs. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Pleiotropic ABC efflux transporter of multiple drugs
IPR003439
Domain description: ABC transporter-like, ATP-binding domain
Occurring in:
  1. Pleiotropic ABC efflux transporter of multiple drugs
IPR013525
Domain description: ABC-2 type transporter, transmembrane domain
Occurring in:
  1. Pleiotropic ABC efflux transporter of multiple drugs
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. Pleiotropic ABC efflux transporter of multiple drugs
IPR043926
Domain description: ABC transporter family G domain
Occurring in:
  1. Pleiotropic ABC efflux transporter of multiple drugs
IPR034003
Domain description: ATP-binding cassette transporter, PDR-like subfamily G, domain 2
Occurring in:
  1. Pleiotropic ABC efflux transporter of multiple drugs
IPR010929
Domain description: CDR ABC transporter
Occurring in:
  1. Pleiotropic ABC efflux transporter of multiple drugs
IPR017871
Domain description: ABC transporter-like, conserved site
Occurring in:
  1. Pleiotropic ABC efflux transporter of multiple drugs
IPR034001
Domain description: ATP-binding cassette transporter, PDR-like subfamily G, domain 1
Occurring in:
  1. Pleiotropic ABC efflux transporter of multiple drugs
IPR005285
Domain description: Pleiotropic drug resistance protein PDR/CDR
Occurring in:
  1. Pleiotropic ABC efflux transporter of multiple drugs
IPR029481
Domain description: Pleiotropic ABC efflux transporter, N-terminal domain
Occurring in:
  1. Pleiotropic ABC efflux transporter of multiple drugs

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