› 7p11

X-ray diffraction
2.1Å resolution

Galectin-8 N-terminal carbohydrate recognition domain in complex with quinoline D-galactal ligand

Released:
DOI: 10.2210/pdb7p11/pdb
Model geometry
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PDB entry 7p11 coloured by chain, front view.
PDB entry 7p11 coloured by chain, side view.
PDB entry 7p11 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-Guided Design of d-Galactal Derivatives with High Affinity and Selectivity for the Galectin-8 N-Terminal Domain.
Hassan M, Baussière F, Guzelj S, Sundin AP, Håkansson M, Kovačič R, Leffler H, Tomašič T, Anderluh M, Jakopin Ž, Nilsson UJ
OpenAccess logo ACS Med Chem Lett 12 1745-1752 (2021)
PMID: 34795863

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126160 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Galectin-8 Chain: A
Molecule details ›
Chain: A
Length: 150 amino acids
Theoretical weight: 16.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00214 (Residues: 7-156; Coverage: 47%)
Gene name: LGALS8
Sequence domains: Galactoside-binding lectin
Galectin-8 Chain: B
Molecule details ›
Chain: B
Length: 151 amino acids
Theoretical weight: 17.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00214 (Residues: 6-156; Coverage: 48%)
Gene name: LGALS8
Sequence domains: Galactoside-binding lectin

Ligands and Environments

2 bound ligands:
Ligand 5KM 2 x 5KM
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P212121
Unit cell:
a: 54.62Å b: 61.394Å c: 85.242Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.205 0.263
Expression system: Escherichia coli

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Citations

3 review citations

Glycomimetics for the inhibition and modulation of lectins.
Leusmann et al. (2023)
2 more

61 mentions without citation

Recent advances in the molecular understanding of glioblastoma.
Bleeker et al. (2012)
60 more

PDB-REDO

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