› 7p5i

X-ray diffraction
1.86Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195563 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kelch-like ECH-associated protein 1 Chain: A
Molecule details ›
Chain: A
Length: 321 amino acids
Theoretical weight: 35.25 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Z2X8 (Residues: 322-624; Coverage: 49%)
Gene names: Inrf2, Keap1, Kiaa0132
Sequence domains: Kelch motif

Ligands and Environments

3 bound ligands:
Ligand CL 1 x CL
Ligand SO4 1 x SO4
Ligand 5X9 1 x 5X9
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-X
Spacegroup: P61
Unit cell:
a: 103.032Å b: 103.032Å c: 55.654Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.194 0.192 0.224
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Activators of Nrf2 to Counteract Neurodegenerative Diseases.
Amoroso et al. (2023)
1 more