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Complex I from E. coli, DDM/LMNG-purified, under Turnover at pH 6, Open state

Source organism: Escherichia coli BL21(DE3)
Biochemical function: quinone binding
Biological process: respiratory electron transport chain
Cellular component: respiratory chain complex I

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00361
Domain description: Proton-conducting membrane transporter
Occurring in:
  1. NADH-quinone oxidoreductase subunit L
  2. NADH-quinone oxidoreductase subunit M
  3. NADH-quinone oxidoreductase subunit N
The deposited structure of PDB entry 7p64 contains 1 copy of Pfam domain PF00361 (Proton-conducting membrane transporter) in NADH-quinone oxidoreductase subunit L. Showing 1 copy in chain I [auth L].
The deposited structure of PDB entry 7p64 contains 1 copy of Pfam domain PF00361 (Proton-conducting membrane transporter) in NADH-quinone oxidoreductase subunit M. Showing 1 copy in chain J [auth M].
The deposited structure of PDB entry 7p64 contains 1 copy of Pfam domain PF00361 (Proton-conducting membrane transporter) in NADH-quinone oxidoreductase subunit N. Showing 1 copy in chain K [auth N].

PF00037
Domain description: 4Fe-4S binding domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit I
The deposited structure of PDB entry 7p64 contains 2 copies of Pfam domain PF00037 (4Fe-4S binding domain) in NADH-quinone oxidoreductase subunit I. Showing 2 copies in chain F [auth I].

PF00662
Domain description: NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus
Occurring in:
  1. NADH-quinone oxidoreductase subunit L
The deposited structure of PDB entry 7p64 contains 1 copy of Pfam domain PF00662 (NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus) in NADH-quinone oxidoreductase subunit L. Showing 1 copy in chain I [auth L].

PF00420
Domain description: NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
Occurring in:
  1. NADH-quinone oxidoreductase subunit K
The deposited structure of PDB entry 7p64 contains 1 copy of Pfam domain PF00420 (NADH-ubiquinone/plastoquinone oxidoreductase chain 4L) in NADH-quinone oxidoreductase subunit K. Showing 1 copy in chain L [auth K].

PF00499
Domain description: NADH-ubiquinone/plastoquinone oxidoreductase chain 6
Occurring in:
  1. NADH-quinone oxidoreductase subunit J
The deposited structure of PDB entry 7p64 contains 1 copy of Pfam domain PF00499 (NADH-ubiquinone/plastoquinone oxidoreductase chain 6) in NADH-quinone oxidoreductase subunit J. Showing 1 copy in chain M [auth J].

PF00146
Domain description: NADH dehydrogenase
Occurring in:
  1. NADH-quinone oxidoreductase subunit H
The deposited structure of PDB entry 7p64 contains 1 copy of Pfam domain PF00146 (NADH dehydrogenase) in NADH-quinone oxidoreductase subunit H. Showing 1 copy in chain G [auth H].

PF01568
Domain description: Molydopterin dinucleotide binding domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit G
The deposited structure of PDB entry 7p64 contains 1 copy of Pfam domain PF01568 (Molydopterin dinucleotide binding domain) in NADH-quinone oxidoreductase subunit G. Showing 1 copy in chain C [auth G].

PF00384
Domain description: Molybdopterin oxidoreductase
Occurring in:
  1. NADH-quinone oxidoreductase subunit G
The deposited structure of PDB entry 7p64 contains 1 copy of Pfam domain PF00384 (Molybdopterin oxidoreductase) in NADH-quinone oxidoreductase subunit G. Showing 1 copy in chain C [auth G].

PF04879
Domain description: Molybdopterin oxidoreductase Fe4S4 domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit G
The deposited structure of PDB entry 7p64 contains 1 copy of Pfam domain PF04879 (Molybdopterin oxidoreductase Fe4S4 domain) in NADH-quinone oxidoreductase subunit G. Showing 1 copy in chain C [auth G].

PF22117
Domain description: NADH-quinone oxidoreductase subunit 3, ferredoxin-like domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit G
The deposited structure of PDB entry 7p64 contains 1 copy of Pfam domain PF22117 (NADH-quinone oxidoreductase subunit 3, ferredoxin-like domain) in NADH-quinone oxidoreductase subunit G. Showing 1 copy in chain C [auth G].

PF10588
Domain description: NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
Occurring in:
  1. NADH-quinone oxidoreductase subunit G
The deposited structure of PDB entry 7p64 contains 1 copy of Pfam domain PF10588 (NADH-ubiquinone oxidoreductase-G iron-sulfur binding region) in NADH-quinone oxidoreductase subunit G. Showing 1 copy in chain C [auth G].

PF13510
Domain description: 2Fe-2S iron-sulfur cluster binding domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit G
The deposited structure of PDB entry 7p64 contains 1 copy of Pfam domain PF13510 (2Fe-2S iron-sulfur cluster binding domain) in NADH-quinone oxidoreductase subunit G. Showing 1 copy in chain C [auth G].

PF10589
Domain description: NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
Occurring in:
  1. NADH-quinone oxidoreductase subunit F
The deposited structure of PDB entry 7p64 contains 1 copy of Pfam domain PF10589 (NADH-ubiquinone oxidoreductase-F iron-sulfur binding region) in NADH-quinone oxidoreductase subunit F. Showing 1 copy in chain A [auth F].

PF01512
Domain description: Respiratory-chain NADH dehydrogenase 51 Kd subunit
Occurring in:
  1. NADH-quinone oxidoreductase subunit F
The deposited structure of PDB entry 7p64 contains 1 copy of Pfam domain PF01512 (Respiratory-chain NADH dehydrogenase 51 Kd subunit) in NADH-quinone oxidoreductase subunit F. Showing 1 copy in chain A [auth F].

PF01257
Domain description: Thioredoxin-like [2Fe-2S] ferredoxin
Occurring in:
  1. NADH-quinone oxidoreductase subunit E
The deposited structure of PDB entry 7p64 contains 1 copy of Pfam domain PF01257 (Thioredoxin-like [2Fe-2S] ferredoxin) in NADH-quinone oxidoreductase subunit E. Showing 1 copy in chain B [auth E].

PF00346
Domain description: Respiratory-chain NADH dehydrogenase, 49 Kd subunit
Occurring in:
  1. NADH-quinone oxidoreductase subunit C/D
The deposited structure of PDB entry 7p64 contains 1 copy of Pfam domain PF00346 (Respiratory-chain NADH dehydrogenase, 49 Kd subunit) in NADH-quinone oxidoreductase subunit C/D. Showing 1 copy in chain D [auth C].

PF00329
Domain description: Respiratory-chain NADH dehydrogenase, 30 Kd subunit
Occurring in:
  1. NADH-quinone oxidoreductase subunit C/D
The deposited structure of PDB entry 7p64 contains 1 copy of Pfam domain PF00329 (Respiratory-chain NADH dehydrogenase, 30 Kd subunit) in NADH-quinone oxidoreductase subunit C/D. Showing 1 copy in chain D [auth C].

PF01058
Domain description: NADH ubiquinone oxidoreductase, 20 Kd subunit
Occurring in:
  1. NADH-quinone oxidoreductase subunit B
The deposited structure of PDB entry 7p64 contains 1 copy of Pfam domain PF01058 (NADH ubiquinone oxidoreductase, 20 Kd subunit) in NADH-quinone oxidoreductase subunit B. Showing 1 copy in chain E [auth B].

PF00507
Domain description: NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
Occurring in:
  1. NADH-quinone oxidoreductase subunit A
The deposited structure of PDB entry 7p64 contains 1 copy of Pfam domain PF00507 (NADH-ubiquinone/plastoquinone oxidoreductase, chain 3) in NADH-quinone oxidoreductase subunit A. Showing 1 copy in chain H [auth A].

InterPro InterPro annotations
IPR003918
Domain description: NADH:ubiquinone oxidoreductase
Occurring in:
  1. NADH-quinone oxidoreductase subunit M
IPR001750
Domain description: NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit
Occurring in:
  1. NADH-quinone oxidoreductase subunit L
  2. NADH-quinone oxidoreductase subunit M
  3. NADH-quinone oxidoreductase subunit N
IPR017896
Domain description: 4Fe-4S ferredoxin-type, iron-sulphur binding domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit I
IPR010226
Domain description: NADH-quinone oxidoreductase, chain I
Occurring in:
  1. NADH-quinone oxidoreductase subunit I
IPR001694
Domain description: NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H
Occurring in:
  1. NADH-quinone oxidoreductase subunit H
IPR006963
Domain description: Molybdopterin oxidoreductase, 4Fe-4S domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit G
IPR019574
Domain description: NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding
Occurring in:
  1. NADH-quinone oxidoreductase subunit G
IPR000283
Domain description: NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site
Occurring in:
  1. NADH-quinone oxidoreductase subunit G
IPR002023
Domain description: NADH-quinone oxidoreductase subunit E-like
Occurring in:
  1. NADH-quinone oxidoreductase subunit E
IPR022885
Domain description: NAD(P)H-quinone oxidoreductase subunit D/H
Occurring in:
  1. NADH-quinone oxidoreductase subunit C/D
IPR006138
Domain description: NADH-ubiquinone oxidoreductase, 20 Kd subunit
Occurring in:
  1. NADH-quinone oxidoreductase subunit B
IPR010096
Domain description: NAD(P)H-quinone oxidoreductase, subunit N/subunit 2
Occurring in:
  1. NADH-quinone oxidoreductase subunit N
IPR001133
Domain description: NADH-ubiquinone oxidoreductase chain 4L/K
Occurring in:
  1. NADH-quinone oxidoreductase subunit K
IPR018086
Domain description: NADH:ubiquinone oxidoreductase, subunit 1, conserved site
Occurring in:
  1. NADH-quinone oxidoreductase subunit H
IPR001041
Domain description: 2Fe-2S ferredoxin-type iron-sulfur binding domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit G
IPR019575
Domain description: NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit F
IPR037207
Domain description: NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily
Occurring in:
  1. NADH-quinone oxidoreductase subunit F
IPR001949
Domain description: NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site
Occurring in:
  1. NADH-quinone oxidoreductase subunit F
IPR037225
Domain description: NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily
Occurring in:
  1. NADH-quinone oxidoreductase subunit F
IPR029014
Domain description: [NiFe]-hydrogenase, large subunit
Occurring in:
  1. NADH-quinone oxidoreductase subunit C/D
IPR010218
Domain description: NADH dehydrogenase, subunit C
Occurring in:
  1. NADH-quinone oxidoreductase subunit C/D
IPR037232
Domain description: NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily
Occurring in:
  1. NADH-quinone oxidoreductase subunit C/D
IPR000440
Domain description: NADH:ubiquinone/plastoquinone oxidoreductase, chain 3
Occurring in:
  1. NADH-quinone oxidoreductase subunit A
IPR010227
Domain description: NADH-quinone oxidoreductase, chain M/4
Occurring in:
  1. NADH-quinone oxidoreductase subunit M
IPR001516
Domain description: NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal
Occurring in:
  1. NADH-quinone oxidoreductase subunit L
IPR018393
Domain description: NADH-plastoquinone oxidoreductase, chain 5 subgroup
Occurring in:
  1. NADH-quinone oxidoreductase subunit L
IPR003945
Domain description: NADH-quinone oxidoreductase, chain 5-like
Occurring in:
  1. NADH-quinone oxidoreductase subunit L
IPR039428
Domain description: NADH-ubiquinone oxidoreductase chain 4L/Mnh complex subunit C1-like
Occurring in:
  1. NADH-quinone oxidoreductase subunit K
IPR001457
Domain description: NADH:ubiquinone/plastoquinone oxidoreductase, chain 6
Occurring in:
  1. NADH-quinone oxidoreductase subunit J
IPR042106
Domain description: NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ
Occurring in:
  1. NADH-quinone oxidoreductase subunit J
IPR017900
Domain description: 4Fe-4S ferredoxin, iron-sulphur binding, conserved site
Occurring in:
  1. NADH-quinone oxidoreductase subunit I
IPR006657
Domain description: Molybdopterin dinucleotide-binding domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit G
IPR009010
Domain description: Aspartate decarboxylase-like domain superfamily
Occurring in:
  1. NADH-quinone oxidoreductase subunit G
IPR006656
Domain description: Molybdopterin oxidoreductase
Occurring in:
  1. NADH-quinone oxidoreductase subunit G
IPR010228
Domain description: NADH:ubiquinone oxidoreductase, subunit G
Occurring in:
  1. NADH-quinone oxidoreductase subunit G
IPR036010
Domain description: 2Fe-2S ferredoxin-like superfamily
Occurring in:
  1. NADH-quinone oxidoreductase subunit G
IPR011538
Domain description: NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit F
IPR011537
Domain description: NADH ubiquinone oxidoreductase, F subunit
Occurring in:
  1. NADH-quinone oxidoreductase subunit F
IPR042128
Domain description: NuoE domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit E
IPR036249
Domain description: Thioredoxin-like superfamily
Occurring in:
  1. NADH-quinone oxidoreductase subunit E
IPR041921
Domain description: NADH-quinone oxidoreductase subunit E, N-terminal
Occurring in:
  1. NADH-quinone oxidoreductase subunit E
IPR001135
Domain description: NADH-quinone oxidoreductase, subunit D
Occurring in:
  1. NADH-quinone oxidoreductase subunit C/D
IPR014029
Domain description: NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site
Occurring in:
  1. NADH-quinone oxidoreductase subunit C/D
IPR020396
Domain description: NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site
Occurring in:
  1. NADH-quinone oxidoreductase subunit C/D
IPR001268
Domain description: NADH:ubiquinone oxidoreductase, 30kDa subunit
Occurring in:
  1. NADH-quinone oxidoreductase subunit C/D
IPR023062
Domain description: NADH dehydrogenase, subunit CD
Occurring in:
  1. NADH-quinone oxidoreductase subunit C/D
IPR006137
Domain description: NADH:ubiquinone oxidoreductase-like, 20kDa subunit
Occurring in:
  1. NADH-quinone oxidoreductase subunit B
IPR023043
Domain description: NAD(P)H-quinone oxidoreductase subunit 3, bacterial/plastid
Occurring in:
  1. NADH-quinone oxidoreductase subunit A
IPR038430
Domain description: NADH:ubiquinone oxidoreductase, subunit 3 superfamily
Occurring in:
  1. NADH-quinone oxidoreductase subunit A

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