› 7pd8

Electron Microscopy
4.2Å resolution

Structure of Adenylyl cyclase 9 in complex with DARPin C4 and MANT-GTP

Released:
DOI: 10.2210/pdb7pd8/pdb
PDB entry 7pd8 coloured by chain, front view.
PDB entry 7pd8 coloured by chain, side view.
PDB entry 7pd8 coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis of adenylyl cyclase 9 activation.
Qi C, Lavriha P, Mehta V, Khanppnavar B, Mohammed I, Li Y, Lazaratos M, Schaefer JV, Dreier B, Plückthun A, Bondar AN, Dessauer CW, Korkhov VM
OpenAccess logo Nat Commun 13 1045 (2022)
PMID: 35210418
Related structures: EMD-13331

Function and Biology Details

Reaction catalysed: 
ATP = 3',5'-cyclic AMP + diphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-122753 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
adenylate cyclase Chain: A
Molecule details ›
Chain: A
Length: 1354 amino acids
Theoretical weight: 151.14 KDa
Source organism: Bos taurus
Expression system: Homo sapiens
UniProt:
  • Canonical: E1BM79 (Residues: 1-1355; Coverage: 100%)
Gene name: ADCY9
Sequence domains: Adenylate and Guanylate cyclase catalytic domain
DARPin C4 Chain: B
Molecule details ›
Chain: B
Length: 147 amino acids
Theoretical weight: 16.04 KDa
Source organism: synthetic construct
Expression system: Escherichia coli

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.2Å
Relevant EMDB volumes: EMD-13331
Expression systems:
  • Homo sapiens
  • Escherichia coli

Quick links

Citations

1 review citation

Alcohol, White Adipose Tissue, and Brown Adipose Tissue: Mechanistic Links to Lipogenesis and Lipolysis.
Li et al. (2023)
8 other articles