Assemblies
Assembly Name:
Insulin A chain and Insulin receptor subunit beta
Multimeric state:
hetero octamer
Accessible surface area:
76576.82 Å2
Buried surface area:
16338.04 Å2
Dissociation area:
1,049.52
Å2
Dissociation energy (ΔGdiss):
-3.35
kcal/mol
Dissociation entropy (TΔSdiss):
10.5
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-134225
Macromolecules
Chains: A, B
Length: 1382 amino acids
Theoretical weight: 156.7 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt: Gene name: INSR
Pfam:
Length: 1382 amino acids
Theoretical weight: 156.7 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt: Gene name: INSR
Pfam:
- Receptor L domain
- Furin-like cysteine rich region
- Fibronectin type III domain
- Insulin receptor trans-membrane segment
- Protein tyrosine and serine/threonine kinase
- Tyrosine-protein kinase, insulin-like receptor
- Receptor L-domain superfamily
- Receptor L-domain
- Furin-like cysteine-rich domain
- Growth factor receptor cysteine-rich domain superfamily
- Furin-like repeat
- Fibronectin type III
- Fibronectin type III superfamily
- Immunoglobulin-like fold
- Insulin receptor, trans-membrane domain
- Protein kinase-like domain superfamily
- Protein kinase domain
- Serine-threonine/tyrosine-protein kinase, catalytic domain
- Tyrosine-protein kinase, catalytic domain
- Protein kinase, ATP binding site
- Tyrosine-protein kinase, active site
- Tyrosine-protein kinase, receptor class II, conserved site
Chains: C, E, I
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
InterPro:
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
- Canonical: P01308 (Residues: 90-110; Coverage: 24%)
InterPro:
Chains: D, F, J
Length: 30 amino acids
Theoretical weight: 3.43 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
Pfam: Insulin/IGF/Relaxin family
InterPro:
Length: 30 amino acids
Theoretical weight: 3.43 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
- Canonical: P01308 (Residues: 25-54; Coverage: 35%)
Pfam: Insulin/IGF/Relaxin family
InterPro: