Structure analysis

Low resolution Cryo-EM structure of full-length insulin receptor bound to 3 insulin, conf 1

Electron Microscopy
6.7Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero octamer (preferred)
Entry contents: 3 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero octamer
Accessible surface area: 76576.82 Å2
Buried surface area: 16338.04 Å2
Dissociation area: 1,049.52 Å2
Dissociation energy (ΔGdiss): -3.35 kcal/mol
Dissociation entropy (TΔSdiss): 10.5 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134225

Macromolecules

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Chains: C, E, I
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
InterPro:

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Chains: D, F, J
Length: 30 amino acids
Theoretical weight: 3.43 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P01308 (Residues: 25-54; Coverage: 35%)
Gene name: INS
Pfam: Insulin/IGF/Relaxin family
InterPro:

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