› › Structure analysis

HHP-C in complex with glycosaminoglycan mimic SOS

X-ray diffraction
2.4Å resolution
PDB entry 7pgn coloured by chain, front view.
PDB entry 7pgn coloured by chain, side view.
PDB entry 7pgn coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hedgehog-interacting protein
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Multimeric state: monomeric
Accessible surface area: 22392.71 Å2
Buried surface area: 703.17 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-188709
Assembly 2
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Assembly Name: Hedgehog-interacting protein
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Multimeric state: monomeric
Accessible surface area: 21895.77 Å2
Buried surface area: 917.09 Å2
Dissociation area: 199.36 Å2
Dissociation energy (ΔGdiss): -0.83 kcal/mol
Dissociation entropy (TΔSdiss): 5.06 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-188709

Macromolecules

Hedgehog-interacting protein
Chains: A, B
Length: 470 amino acids
Theoretical weight: 52.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96QV1 (Residues: 213-670; Coverage: 67%)
Gene names: HHIP, HIP, UNQ5825/PRO19644
Pfam:
InterPro:
Hedgehog-interacting protein in PDB entry 7pgn, assembly 1, front view.
Hedgehog-interacting protein in PDB entry 7pgn, assembly 1, side view.
Hedgehog-interacting protein in PDB entry 7pgn, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q96QV1  
147050100150200250300350400450
 
200400ETGKHNCFCIQEVVSGLRQPVGALHSGDGSQRLFILEKEGYVKILTPEGEIFKEPYLDIHKLVQSGIKGGDERGLLSLAFHPNYKKNGKLYVSYTTNQERWAIGPHDHILRVVEYTVSRKNPHQVDLRTARVFLEVAELHRKHLGGQLLFGPDGFLYIILGDGMITLDDMEEMDGLSDFTGSVLRLDVDTDMCNVPYSIPRSNPHFNSTNQPPEVFAHGLHDPGRCAVDRHPTDININLTILCSDSNGKNRSSARILQIIKGKDYESEPSLLEFKPFSNGPLVGGFVYRGCQSERLYGSYVFGDRNGNFLTLQQSPVTKQWQEKPLCLGTSGSCRGYFSGHILGFGEDELGEVYILSSSKSMTQTHNGKLYKIVDPKRPLMPEECRATVQPAQTLTSECSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQCEQVDGTKHHHHHH
UniProt
Q96QV1
Chains
Domains
Secondary structure
Ligand binding sites
Sequence conservation
Variants
Molecule details ›

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