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Chimeric carminomycin-4-O-methyltransferase (DnrK) with regions from 10-hydroxylase RdmB and 10-decarboxylase TamK

Source organisms:
Biochemical function: O-methyltransferase activity
Biological process: not assigned
Cellular component: not assigned

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EC 2.1.1.292: Carminomycin 4-O-methyltransferase

Reaction catalysed:
S-adenosyl-L-methionine + carminomycin = S-adenosyl-L-homocysteine + daunorubicin
Systematic name:
S-adenosyl-L-methionine:carminomycin 4-O-methyltransferase
Alternative Name(s):
  • DauK
  • DnrK

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00891
Domain description: O-methyltransferase domain
Occurring in:
  1. Aclacinomycin 10-hydroxylase RdmB; Carminomycin 4-O-methyltransferase DnrK; O-methyltransferase domain-containing protein
The deposited structure of PDB entry 7phe contains 4 copies of Pfam domain PF00891 (O-methyltransferase domain) in Aclacinomycin 10-hydroxylase RdmB. Showing 2 copies in chain A.

InterPro InterPro annotations
IPR016461
Domain description: O-methyltransferase COMT-type
Occurring in:
  1. Aclacinomycin 10-hydroxylase RdmB; Carminomycin 4-O-methyltransferase DnrK; O-methyltransferase domain-containing protein
IPR029063
Domain description: S-adenosyl-L-methionine-dependent methyltransferase superfamily
Occurring in:
  1. Aclacinomycin 10-hydroxylase RdmB; Carminomycin 4-O-methyltransferase DnrK; O-methyltransferase domain-containing protein
IPR001077
Domain description: O-methyltransferase domain
Occurring in:
  1. Aclacinomycin 10-hydroxylase RdmB; Carminomycin 4-O-methyltransferase DnrK; O-methyltransferase domain-containing protein
IPR036390
Domain description: Winged helix DNA-binding domain superfamily
Occurring in:
  1. Aclacinomycin 10-hydroxylase RdmB; Carminomycin 4-O-methyltransferase DnrK; O-methyltransferase domain-containing protein
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. Aclacinomycin 10-hydroxylase RdmB; Carminomycin 4-O-methyltransferase DnrK; O-methyltransferase domain-containing protein

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