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LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria

Source organism: Pseudomonas aeruginosa PAO1
Biochemical function: UDP-3-O-acyl-N-acetylglucosamine deacetylase activity
Biological process: carbohydrate derivative metabolic process
Cellular component: not assigned

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EC 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase

Reaction catalysed:
UDP-3-O-((3R)-3-hydroxyacyl)-N-acetyl-alpha-D-glucosamine + H(2)O = UDP-3-O-((3R)-3-hydroxyacyl)-alpha-D-glucosamine + acetate
Systematic name:
UDP-3-O-((3R)-3-hydroxymyristoyl)-N-acetyl-alpha-D-glucosamine amidohydrolase
Alternative Name(s):
  • Deacetylase LpxC
  • LpxC
  • LpxC deacetylase
  • LpxC enzyme
  • UDP-(3-O-(R-3-hydroxymyristoyl))-N-acetylglucosamine deacetylase
  • UDP-(3-O-acyl)-N-acetylglucosamine deacetylase
  • UDP-3-O-((3R)-3-hydroxymyristoyl)-N-acetylglucosamine amidohydrolase
  • UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase
  • UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase
  • UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase
  • UDP-3-O-acyl-GlcNAc deacetylase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF03331
Domain description: UDP-3-O-acyl N-acetylglycosamine deacetylase
Occurring in:
  1. UDP-3-O-acyl-N-acetylglucosamine deacetylase
The deposited structure of PDB entry 7pkm contains 1 copy of Pfam domain PF03331 (UDP-3-O-acyl N-acetylglycosamine deacetylase) in UDP-3-O-acyl-N-acetylglucosamine deacetylase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR004463
Domain description: UDP-3-O-acyl N-acetylglucosamine deacetylase
Occurring in:
  1. UDP-3-O-acyl-N-acetylglucosamine deacetylase
IPR020568
Domain description: Ribosomal protein uS5 domain 2-type superfamily
Occurring in:
  1. UDP-3-O-acyl-N-acetylglucosamine deacetylase
IPR011334
Domain description: UDP-3-O-acyl N-acetylglucosamine deacetylase, C-terminal
Occurring in:
  1. UDP-3-O-acyl-N-acetylglucosamine deacetylase
IPR015870
Domain description: UDP-3-O-acyl N-acetylglucosamine deacetylase, N-terminal
Occurring in:
  1. UDP-3-O-acyl-N-acetylglucosamine deacetylase

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